用于抗菌应用的银纳米粒子装饰聚合物囊泡的原位制备技术

IF 2.5 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Fen Zhang, Qian Yao, Yanling Niu, Xiaoqi Chen, Haijun Zhou, Lu Bai, Zejuan Kong, Yantao Li, Hua Cheng
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引用次数: 0

摘要

本研究制备了具有良好抗菌性能的银/聚合物囊泡复合纳米粒子。利用聚乙烯吡咯烷酮(PVP)还原硝酸银(AgNO3),通过 Ag+ 离子与囊泡上的氮原子之间的配位键作用,在交联囊泡膜上原位制备银纳米粒子(AgNPs)。X 射线衍射 (XRD)、紫外可见光谱 (UV-vis) 和透射电子显微镜 (TEM) 分析证实了 AgNPs 在囊泡上的形成。抗菌测试表明,经 AgNP 装饰的囊泡对革兰氏阴性菌(大肠杆菌)和革兰氏阳性菌(金黄色葡萄球菌)均具有良好的抗菌活性。AgNP 装饰囊泡对大肠杆菌和金黄色葡萄球菌的最小抑菌浓度 (MIC) 值分别为 8.4 和 9.6 μg/mL。对 A549 细胞进行的细胞存活率分析表明,当 AgNP 浓度不超过 MIC 值时,毒性很低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

In Situ Fabrication of Silver Nanoparticle-Decorated Polymeric Vesicles for Antibacterial Applications

In Situ Fabrication of Silver Nanoparticle-Decorated Polymeric Vesicles for Antibacterial Applications

Silver/polymeric vesicle composite nanoparticles with good antibacterial properties were fabricated in this study. Silver nanoparticles (AgNPs) were prepared in situ on cross-linked vesicle membranes through the reduction of silver nitrate (AgNO3) using polyvinylpyrrolidone (PVP) via coordination bonding between the Ag+ ions and the nitrogen atoms on the vesicles. X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-vis), and transmission electron microscopy (TEM) analyses confirmed the formation of AgNPs on the vesicles. The antibacterial test demonstrated good antibacterial activity against both Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) for the produced AgNP-decorated vesicles. The minimum inhibitory concentration (MIC) values of the AgNP-decorated vesicles for E. coli and S. aureus were 8.4 and 9.6 μg/mL, respectively. Cell viability analysis on the A549 cells indicated that the toxicity was low when the AgNP concentrations did not exceed the MIC values, and the wound healing test confirmed the good antibacterial properties of the AgNP-decorated vesicles.

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来源期刊
ChemistryOpen
ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.80
自引率
4.30%
发文量
143
审稿时长
1 months
期刊介绍: ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
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