含有原子分散铁原子的 FeNC 作为光敏剂用于光动力和光热联合疗法

IF 5.9 3区材料科学 Q2 CHEMISTRY, PHYSICAL

FlatChem Pub Date : 2024-04-20 DOI:10.1016/j.flatc.2024.100663

Dan Li , Mengyao Zhang , Yudai Huang , Xin Hu , Junqing Hu

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引用次数: 0

摘要

这项研究探讨了光动力疗法（PDT）和光热疗法（PTT）在抗化疗耐药疾病中的疗效。本研究的重点是通过开发具有优异光稳定性的碳氮铁（FeNC）纳米粒子，利用光动力疗法和光热疗法的协同效应提高肿瘤治疗效果。这些纳米粒子是 PDT/PTT 联合治疗的光敏剂，在 808 纳米波长的照射下可产生 I 型和 II 型 ROS 和热量。值得注意的是，FeNC 纳米粒子显示出卓越的光热转换效率（34%），超过了常用的 PTT 光敏剂。体外和体内实验证实，FeNC 作为光敏剂可有效抑制肿瘤。总之，FeNC 纳米粒子在 PTT/PDT 协同治疗肿瘤方面具有广阔的应用前景。

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FeNC with atomically dispersed iron atoms as a photosensitizer for combined photodynamic and photothermal therapy

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FeNC with atomically dispersed iron atoms as a photosensitizer for combined photodynamic and photothermal therapy

This research explores the efficacy of photodynamic therapy (PDT) and photothermal therapy (PTT) in combating chemotherapy-resistant diseases. This study focuses on enhancing tumor treatment effectiveness by leveraging the synergetic effects of combining PDT and PTT through the development of Fe-nitrogen-carbon (FeNC) nanoparticles with superior photostability. These nanoparticles, functioning as photosensitizers for the combined PDT/PTT treatment, can generate both type I and type II ROS and heat upon 808 nm irradiation. Notably, the FeNC nanoparticles demonstrate an exceptional photothermal conversion efficiency (34 %), surpassing commonly used PTT photosensitizers. In vitro and in vivo experiments corroborate the efficiency of FeNC as a photosensitizer in achieving significant tumor inhibition. In conclusion, the FeNC nanoparticles present promising applicability in the synergistic PTT/PDT treatment of tumors.

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来源期刊

FlatChem Multiple-

CiteScore

8.40

自引率

6.50%

发文量

104

审稿时长

26 days

期刊介绍： FlatChem - Chemistry of Flat Materials, a new voice in the community, publishes original and significant, cutting-edge research related to the chemistry of graphene and related 2D & layered materials. The overall aim of the journal is to combine the chemistry and applications of these materials, where the submission of communications, full papers, and concepts should contain chemistry in a materials context, which can be both experimental and/or theoretical. In addition to original research articles, FlatChem also offers reviews, minireviews, highlights and perspectives on the future of this research area with the scientific leaders in fields related to Flat Materials. Topics of interest include, but are not limited to, the following: -Design, synthesis, applications and investigation of graphene, graphene related materials and other 2D & layered materials (for example Silicene, Germanene, Phosphorene, MXenes, Boron nitride, Transition metal dichalcogenides) -Characterization of these materials using all forms of spectroscopy and microscopy techniques -Chemical modification or functionalization and dispersion of these materials, as well as interactions with other materials -Exploring the surface chemistry of these materials for applications in: Sensors or detectors in electrochemical/Lab on a Chip devices, Composite materials, Membranes, Environment technology, Catalysis for energy storage and conversion (for example fuel cells, supercapacitors, batteries, hydrogen storage), Biomedical technology (drug delivery, biosensing, bioimaging)