无特殊类型和小叶混合型原发性乳腺癌的转移灶显示出唯一的小叶组织学特征

IF 5.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Pub Date : 2024-04-12 DOI:10.1016/j.breast.2024.103732

Gitte Zels , Karen Van Baelen , Maxim De Schepper , Kristien Borremans , Tatjana Geukens , Edoardo Isnaldi , Hava Izci , Sophia Leduc , Amena Mahdami , Marion Maetens , Ha Linh Nguyen , Anirudh Pabba , François Richard , Josephine Van Cauwenberge , Ann Smeets , Ines Nevelsteen , Patrick Neven , Hans Wildiers , Wouter Van Den Bogaert , Giuseppe Floris , Christine Desmedt

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引用次数: 0

摘要

无特殊类型浸润性乳腺癌（IBC-NST）和浸润性小叶癌（ILC）混合组织学的原发性肿瘤约占所有乳腺癌患者的百分之五，但对其转移水平的研究却不足。在此，我们对 UPTIDER（NCT04531696）尸检组织捐赠项目中两名原发性 IBC-NST/ILC 混合型患者的转移灶组织学进行了鉴定。尸检时收集到的14个和43个转移灶的形态特征和E-cadherin染色模式与纯ILC一致。虽然我们的研究结果仍需进一步验证，但它们可能会对目前的临床实践和用于这些患者的成像模式提出挑战。

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Metastases of primary mixed no-special type and lobular breast cancer display an exclusive lobular histology

Primary tumors with a mixed invasive breast carcinoma of no-special type (IBC-NST) and invasive lobular cancer (ILC) histology are present in approximately five percent of all patients with breast cancer and are understudied at the metastatic level. Here, we characterized the histology of metastases from two patients with primary mixed IBC-NST/ILC from the postmortem tissue donation program UPTIDER (NCT04531696). The 14 and 43 metastatic lesions collected at autopsy had morphological features and E-cadherin staining patterns consistent with pure ILC. While our findings still require further validation, they may challenge current clinical practice and imaging modalities used in these patients.

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来源期刊

Breast 医学-妇产科学

CiteScore

8.70

自引率

2.60%

发文量

165

审稿时长

59 days

期刊介绍： The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.