来自真菌 Arthrinium sp. ZS03 的具有抗菌活性的新 pimarane 二萜类化合物

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2024-04-01 DOI:10.1016/S1875-5364(24)60629-1

Songfeng ZHAO , Ziwei JING

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引用次数: 0

摘要

通过对与Acorus tatarinowii Schott相关联的内生真菌Arthrinium sp. ZS03进行全面的化学研究，发现了11种pimarane二萜（化合物1-11），其中包括7种新化合物，命名为arthrinoids A-G（1-7）。通过广泛的光谱技术、电子圆二色性量子化学计算和单晶 X 射线衍射分析，确定了这些化合物的结构和绝对构型。此外，7 对肺炎克雷伯菌具有抑制活性，与参考抗生素阿米卡星相当，最低抑制浓度（MIC）为 8 μg-mL-1。

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New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03

A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1–11), including seven novel compounds designated arthrinoids A–G (1–7). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity against Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL⁻¹.

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.