来自真菌 Arthrinium sp. ZS03 的具有抗菌活性的新 pimarane 二萜类化合物

IF 4 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Songfeng ZHAO , Ziwei JING
{"title":"来自真菌 Arthrinium sp. ZS03 的具有抗菌活性的新 pimarane 二萜类化合物","authors":"Songfeng ZHAO ,&nbsp;Ziwei JING","doi":"10.1016/S1875-5364(24)60629-1","DOIUrl":null,"url":null,"abstract":"<div><p>A comprehensive chemical study of the endophytic fungus <em>Arthrinium</em> sp. ZS03, associated with <em>Acorus tatarinowii</em> Schott, yielded eleven pimarane diterpenoids (compounds <strong>1</strong>–<strong>11</strong>), including seven novel compounds designated arthrinoids A–G (<strong>1</strong>–<strong>7</strong>). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, <strong>7</strong> demonstrated inhibitory activity against <em>Klebsiella pneumoniae</em>, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL<sup>−1</sup>.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03\",\"authors\":\"Songfeng ZHAO ,&nbsp;Ziwei JING\",\"doi\":\"10.1016/S1875-5364(24)60629-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A comprehensive chemical study of the endophytic fungus <em>Arthrinium</em> sp. ZS03, associated with <em>Acorus tatarinowii</em> Schott, yielded eleven pimarane diterpenoids (compounds <strong>1</strong>–<strong>11</strong>), including seven novel compounds designated arthrinoids A–G (<strong>1</strong>–<strong>7</strong>). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, <strong>7</strong> demonstrated inhibitory activity against <em>Klebsiella pneumoniae</em>, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL<sup>−1</sup>.</p></div>\",\"PeriodicalId\":10002,\"journal\":{\"name\":\"Chinese Journal of Natural Medicines\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Natural Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1875536424606291\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1875536424606291","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0

摘要

通过对与Acorus tatarinowii Schott相关联的内生真菌Arthrinium sp. ZS03进行全面的化学研究,发现了11种pimarane二萜(化合物1-11),其中包括7种新化合物,命名为arthrinoids A-G(1-7)。通过广泛的光谱技术、电子圆二色性量子化学计算和单晶 X 射线衍射分析,确定了这些化合物的结构和绝对构型。此外,7 对肺炎克雷伯菌具有抑制活性,与参考抗生素阿米卡星相当,最低抑制浓度(MIC)为 8 μg-mL-1。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03

A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 111), including seven novel compounds designated arthrinoids A–G (17). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity against Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL−1.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Chinese Journal of Natural Medicines
Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY
CiteScore
7.50
自引率
4.30%
发文量
2235
期刊介绍: The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信