水凝胶在颞下颌关节疾病组织工程修复中的应用

IF 5.7 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Xuan Wang, Fushuang Liu, Tianyi Wang, Yikai He and Yongwen Guo
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引用次数: 0

摘要

流行病学研究表明,60%-70% 的成年人会出现 TMD 症状。TMD 造成的炎症损伤很容易导致颞下颌关节的关节盘、髁状软骨、软骨下骨和肌肉缺损,从而引起疼痛。尽管治疗 TMD 的方法多种多样,但现有的治疗方案很少能实现永久康复。这种必要性促使人们寻找新的方法。水凝胶是一种含水量较高的聚合物,因其具有良好的生物相容性和机械特性,与人体组织相似,已被广泛应用于组织工程和再生领域。在 TMD 治疗方面,大量实验证明,水凝胶在关节盘修复、软骨再生、肌肉修复、止痛和药物输送等方面显示出良好的效果。本综述旨在根据最新研究成果,总结水凝胶在 TMD 治疗中的应用。它还强调了目前与 TMD 治疗相关的水凝胶研究中存在的不足,并概述了水凝胶在未来治疗颞下颌关节疾病中的广泛应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Applications of hydrogels in tissue-engineered repairing of temporomandibular joint diseases

Applications of hydrogels in tissue-engineered repairing of temporomandibular joint diseases

Epidemiological studies reveal that symptoms of temporomandibular joint disorders (TMDs) occur in 60–70% of adults. The inflammatory damage caused by TMDs can easily lead to defects in the articular disc, condylar cartilage, subchondral bone and muscle of the temporomandibular joint (TMJ) and cause pain. Despite the availability of various methods for treating TMDs, few existing treatment schemes can achieve permanent recovery. This necessity drives the search for new approaches. Hydrogels, polymers with high water content, have found widespread use in tissue engineering and regeneration due to their excellent biocompatibility and mechanical properties, which resemble those of human tissues. In the context of TMD therapy, numerous experiments have demonstrated that hydrogels show favorable effects in aspects such as articular disc repair, cartilage regeneration, muscle repair, pain relief, and drug delivery. This review aims to summarize the application of hydrogels in the therapy of TMDs based on recent research findings. It also highlights deficiencies in current hydrogel research related to TMD therapy and outlines the broad potential of hydrogel applications in treating TMJ diseases in the future.

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来源期刊
Biomaterials Science
Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.50%
发文量
556
期刊介绍: Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.
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