超越抗病毒：IFN-I 在大脑发育中的作用

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-04-20 DOI:10.1016/j.it.2024.04.004

Christopher A. Baker, Akiko Iwasaki

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引用次数: 0

摘要

干扰素和中枢神经系统常驻巨噬细胞（小胶质细胞）因各自在抗病毒防御和吞噬中的作用而广为人知。最近，Escoubas、Dorman 等人利用一个经典的实验范例研究了活动依赖性神经可塑性，发现了小胶质细胞 I 型干扰素信号在小鼠大脑发育过程中清除多余神经元的作用。

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Beyond antiviral: role of IFN-I in brain development

Interferons and central nervous system resident macrophages, microglia, are well-known for their respective roles in antiviral defense and phagocytosis. Using a classic experimental paradigm for examining activity-dependent neural plasticity, Escoubas, Dorman, et al. recently identified a role for microglial type I interferon signaling in the clearance of unwanted neurons during mouse brain development.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.