用于闭环神经调制和传感的多模态技术

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Lizhu Li, Bozhen Zhang, Wenxin Zhao, David Sheng, Lan Yin, Xing Sheng, Dezhong Yao
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引用次数: 0

摘要

研究神经回路和治疗神经系统疾病的现有方法通常基于物理和化学线索来操纵和记录神经活动。这些方法通常涉及预定义、僵化和不可改变的信号模式,无法根据患者的病情或神经活动进行实时调整。随着神经接口的不断发展,对神经疾病和神经回路进行自适应和可修改治疗的体内研究现已成为可能。在这篇综述中,我们总结了当前和潜在的各种模式的整合,以实现神经系统中精确的闭环调制和传感。我们将重点介绍能产生或检测电、磁、光、声或化学信号的先进材料、设备或系统,并利用这些信号与神经细胞、组织和网络互动,进行闭环检测。此外,我们还阐述了开发闭环技术对于诊断和治疗癫痫、抑郁症等神经系统疾病、脊髓损伤患者的康复以及探索大脑神经回路功能的意义。本文受版权保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multimodal Technologies for Closed-Loop Neural Modulation and Sensing

Multimodal Technologies for Closed-Loop Neural Modulation and Sensing

Existing methods for studying neural circuits and treating neurological disorders are typically based on physical and chemical cues to manipulate and record neural activities. These approaches often involve predefined, rigid, and unchangeable signal patterns, which cannot be adjusted in real time according to the patient's condition or neural activities. With the continuous development of neural interfaces, conducting in vivo research on adaptive and modifiable treatments for neurological diseases and neural circuits is now possible. In this review, current and potential integration of various modalities to achieve precise, closed-loop modulation, and sensing in neural systems are summarized. Advanced materials, devices, or systems that generate or detect electrical, magnetic, optical, acoustic, or chemical signals are highlighted and utilized to interact with neural cells, tissues, and networks for closed-loop interrogation. Further, the significance of developing closed-loop techniques for diagnostics and treatment of neurological disorders such as epilepsy, depression, rehabilitation of spinal cord injury patients, and exploration of brain neural circuit functionality is elaborated.

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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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