GPD1 relieves the proliferation, migration and invasion abilities of oral cancer cells by inhibiting mitochondrial function

Background

Oral cancer is a very familiar tumor together with a gravely effect on the life of human. GPD1 has been verified to join into the regulation of multifold cancers’ progression through being a suppressor. Interestingly, it has been revealed that GPD1 overexpression activated the PI3K/AKT signaling pathway. However, the regulatory functions of GPD1 on the PI3K/AKT/GSK-3β pathway in oral cancer progression keep vague, and need more investigations.

Objectives

To investigate the regulation function and mechanism of GPD1 in oral cancer.

Results

It was demonstrated that GPD1 exhibited lower expression in oral cancer. Moreover, overexpression of GPD1 relieved cell proliferation and strengthened cell apoptosis in oral cancer. Overexpression of GPD1 weakened cell migration and invasion in oral cancer. In addition, it was confirmed that overexpression of GPD1 suppressed mitochondrial function in oral cancer. At last, it was illustrated that GPD1 triggered the PI3K/AKT/GSK-3β pathway.

Conclusion

For the first time, this work manifested that GPD1 inhibited the proliferation, migration and invasion of oral cancer cells by inhibiting mitochondrial function through triggering the PI3K/AKT/GSK-3β pathway. This discovery hinted that GPD1 may be a serviceable biomarker for the treatment of oral cancer.