儿童 COVID-19 急性后遗症的范围：从MIS-C到长COVID

IF 8.1 1区医学 Q1 VIROLOGY

Annual Review of Virology Pub Date : 2024-04-18 DOI:10.1146/annurev-virology-093022-011839

Abigail S. Kane, Madeleine Godfrey, Magali Noval Rivas, Moshe Arditi, Alessio Fasano, Lael M. Yonker

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引用次数: 0

摘要

在 COVID-19 大流行之后，SARS-CoV-2 感染对儿童的影响继续演变。虽然危及生命的儿童多系统炎症综合征（MIS-C）已变得罕见，但在急性 SARS-CoV-2 感染缓解后，由于持续的免疫激活而产生的长期症状会造成严重的健康后遗症，并继续造成经济负担。共同的病理生理学机制将 MIS-C 和长期 COVID 置于以肠道菌群失调、肠道通透性增加和不同程度的免疫失调为特征的大量感染后病症中。从 MIS-C 中获得的启示将有助于我们了解 COVID 更为轻微和普遍的急性后遗症，并最终指导我们改善儿童 SARS-CoV-2 感染后并发症的诊断和管理。

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The Spectrum of Postacute Sequelae of COVID-19 in Children: From MIS-C to Long COVID

The effects of SARS-CoV-2 infection on children continue to evolve following the onset of the COVID-19 pandemic. Although life-threatening multisystem inflammatory syndrome in children (MIS-C) has become rare, long-standing symptoms stemming from persistent immune activation beyond the resolution of acute SARS-CoV-2 infection contribute to major health sequelae and continue to pose an economic burden. Shared pathophysiologic mechanisms place MIS-C and long COVID within a vast spectrum of postinfectious conditions characterized by intestinal dysbiosis, increased gut permeability, and varying degrees of immune dysregulation. Insights obtained from MIS-C will help shape our understanding of the more indolent and prevalent postacute sequelae of COVID and ultimately guide efforts to improve diagnosis and management of postinfectious complications of SARS-CoV-2 infection in children.

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来源期刊

Annual Review of Virology VIROLOGY-

CiteScore

19.40

自引率

0.90%

发文量

期刊介绍： The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.