Surui Ai, Le Liu, Yuan Xue, Xiaoou Cheng, Meng Li, Qihong Deng
{"title":"产前接触空气污染物与儿童过敏性疾病相关:哪种污染物、何时暴露、何种疾病?系统回顾与元分析","authors":"Surui Ai, Le Liu, Yuan Xue, Xiaoou Cheng, Meng Li, Qihong Deng","doi":"10.1007/s12016-024-08987-3","DOIUrl":null,"url":null,"abstract":"<p>This systematic review aims to identify the association between prenatal exposure to air pollutants and allergic diseases in children, focusing on specific pollutants, timing of exposure, and associated diseases. We searched PubMed, Scopus, and Web of Science for English articles until May 1, 2023, examining maternal exposure to outdoor air pollutants (PM<sub>1</sub>, PM<sub>2.5</sub>, PM<sub>10</sub>, NO, NO<sub>2</sub>, SO<sub>2</sub>, CO, and O<sub>3</sub>) during pregnancy and child allergic diseases (atopic dermatitis (AD), food allergy (FA), asthma (AT) and allergic rhinitis (AR)/hay fever (HF)). The final 38 eligible studies were included in the meta-analysis. Exposure to PM<sub>2.5</sub> and NO<sub>2</sub> during pregnancy was associated with the risk of childhood AD, with pooled <i>ORs</i> of 1.34 (95% confidence interval <i>(CI)</i>, 1.10–1.63) and 1.10 (95%<i>CI</i>, 1.05–1.15) per 10 µg/m<sup>3</sup> increase, respectively. Maternal exposure to PM<sub>1</sub>, PM<sub>2.5</sub>, and NO<sub>2</sub> with a 10 µg/m<sup>3</sup> increase posed a risk for AT, with pooled <i>ORs</i> of 1.34 (95%<i>CI</i>, 1.17–1.54), 1.11 (95%<i>CI</i>, 1.05–1.18), and 1.07 (95%<i>CI</i>, 1.02–1.12), respectively. An increased risk of HF was observed for PM<sub>2.5</sub> and NO<sub>2</sub> with a 10 µg/m<sup>3</sup> increase, with <i>ORs</i> of 1.36 (95%<i>CI</i>, 1.17–1.58) and 1.26 (95%<i>CI</i>, 1.08–1.48), respectively. Traffic-related air pollutants (TRAP), particularly PM<sub>2.5</sub> and NO<sub>2</sub>, throughout pregnancy, pose a pervasive risk for childhood allergies. Different pollutants may induce diverse allergic diseases in children across varying perinatal periods. AT is more likely to be induced by outdoor air pollutants as a health outcome. More research is needed to explore links between air pollution and airway-derived food allergies.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":null,"pages":null},"PeriodicalIF":8.4000,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? 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Exposure to PM<sub>2.5</sub> and NO<sub>2</sub> during pregnancy was associated with the risk of childhood AD, with pooled <i>ORs</i> of 1.34 (95% confidence interval <i>(CI)</i>, 1.10–1.63) and 1.10 (95%<i>CI</i>, 1.05–1.15) per 10 µg/m<sup>3</sup> increase, respectively. Maternal exposure to PM<sub>1</sub>, PM<sub>2.5</sub>, and NO<sub>2</sub> with a 10 µg/m<sup>3</sup> increase posed a risk for AT, with pooled <i>ORs</i> of 1.34 (95%<i>CI</i>, 1.17–1.54), 1.11 (95%<i>CI</i>, 1.05–1.18), and 1.07 (95%<i>CI</i>, 1.02–1.12), respectively. An increased risk of HF was observed for PM<sub>2.5</sub> and NO<sub>2</sub> with a 10 µg/m<sup>3</sup> increase, with <i>ORs</i> of 1.36 (95%<i>CI</i>, 1.17–1.58) and 1.26 (95%<i>CI</i>, 1.08–1.48), respectively. Traffic-related air pollutants (TRAP), particularly PM<sub>2.5</sub> and NO<sub>2</sub>, throughout pregnancy, pose a pervasive risk for childhood allergies. 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引用次数: 0
摘要
本系统综述旨在确定产前暴露于空气污染物与儿童过敏性疾病之间的关系,重点关注特定污染物、暴露时间和相关疾病。我们检索了 PubMed、Scopus 和 Web of Science 上截至 2023 年 5 月 1 日的英文文章,研究了母亲在怀孕期间暴露于室外空气污染物(PM1、PM2.5、PM10、NO、NO2、SO2、CO 和 O3)与儿童过敏性疾病(特应性皮炎 (AD)、食物过敏 (FA)、哮喘 (AT) 和过敏性鼻炎 (AR)/ 干草热 (HF))之间的关系。最终 38 项符合条件的研究被纳入荟萃分析。孕期暴露于PM2.5和二氧化氮与儿童注意力缺失症的风险有关,每增加10微克/立方米,汇总OR值分别为1.34(95%置信区间(CI),1.10-1.63)和1.10(95%CI,1.05-1.15)。孕产妇暴露于 PM1、PM2.5 和 NO2(浓度每立方米增加 10 微克)会增加 AT 风险,汇总 OR 分别为 1.34(95%CI,1.17-1.54)、1.11(95%CI,1.05-1.18)和 1.07(95%CI,1.02-1.12)。PM2.5和二氧化氮每增加10微克/立方米,患高血压的风险就会增加,OR值分别为1.36(95%CI,1.17-1.58)和1.26(95%CI,1.08-1.48)。与交通有关的空气污染物(TRAP),尤其是 PM2.5 和二氧化氮,在整个妊娠期对儿童过敏症构成普遍风险。在不同的围产期,不同的污染物可能诱发儿童不同的过敏性疾病。作为一种健康结果,过敏性鼻炎更有可能由室外空气污染物诱发。需要进行更多的研究来探索空气污染与气道源性食物过敏之间的联系。
Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis
This systematic review aims to identify the association between prenatal exposure to air pollutants and allergic diseases in children, focusing on specific pollutants, timing of exposure, and associated diseases. We searched PubMed, Scopus, and Web of Science for English articles until May 1, 2023, examining maternal exposure to outdoor air pollutants (PM1, PM2.5, PM10, NO, NO2, SO2, CO, and O3) during pregnancy and child allergic diseases (atopic dermatitis (AD), food allergy (FA), asthma (AT) and allergic rhinitis (AR)/hay fever (HF)). The final 38 eligible studies were included in the meta-analysis. Exposure to PM2.5 and NO2 during pregnancy was associated with the risk of childhood AD, with pooled ORs of 1.34 (95% confidence interval (CI), 1.10–1.63) and 1.10 (95%CI, 1.05–1.15) per 10 µg/m3 increase, respectively. Maternal exposure to PM1, PM2.5, and NO2 with a 10 µg/m3 increase posed a risk for AT, with pooled ORs of 1.34 (95%CI, 1.17–1.54), 1.11 (95%CI, 1.05–1.18), and 1.07 (95%CI, 1.02–1.12), respectively. An increased risk of HF was observed for PM2.5 and NO2 with a 10 µg/m3 increase, with ORs of 1.36 (95%CI, 1.17–1.58) and 1.26 (95%CI, 1.08–1.48), respectively. Traffic-related air pollutants (TRAP), particularly PM2.5 and NO2, throughout pregnancy, pose a pervasive risk for childhood allergies. Different pollutants may induce diverse allergic diseases in children across varying perinatal periods. AT is more likely to be induced by outdoor air pollutants as a health outcome. More research is needed to explore links between air pollution and airway-derived food allergies.
期刊介绍:
Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership.
The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.