绵羊颈动脉通路植入 Impella 5.5 长期机械循环支持动物模型的可行性

IF 1.1 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Shusuke Imaoka, Tomohiro Nishinaka, Toshihide Mizuno, Akihide Umeki, Takashi Murakami, Tomonori Tsukiya, Masashi Kawamura, Shigeru Miyagawa
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引用次数: 0

摘要

Impella 是一种基于导管的血管内微轴泵机械循环支持装置,用于左心室支持和卸载。然而,目前还缺乏评估延长左心室卸载时间对心脏恢复的影响的非临床研究。我们需要一种使用 Impella 植入式微创手术的动物模型来实现长期支持。本研究旨在评估通过颈动脉途径将 Impella 5.5 植入绵羊体内进行长期支持的动物模型的可行性。Impella 5.5 通过左颈动脉近端区域植入四只绵羊体内,无需进行开胸手术,并通过冠状动脉微栓塞诱发心肌损伤。Impella 5.5 的支持作用维持了 4 周,并对动物进行了观察。植入后2周和4周,使用心脏计算机断层扫描评估Impella 5.5的位置和心脏功能。观察发现,Impella 5.5 在清醒和麻醉状态下的流速差异取决于装置的位置。在有意识状态下,流入口位于左心室乳头肌上方的动物在最大性能水平下的流速相对较高,且不会出现抽吸警报。主动脉瓣出现病理变化。通过颈动脉通道将 Impella 5.5 植入绵羊体内并支持 4 周的心肌损伤动物模型是可行的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Feasibility of an animal model for long-term mechanical circulatory support with Impella 5.5 implanted through carotid artery access in sheep

Feasibility of an animal model for long-term mechanical circulatory support with Impella 5.5 implanted through carotid artery access in sheep

Impella is a mechanical circulatory support device of a catheter-based intravascular microaxial pump for left ventricular support and unloading. However, nonclinical studies assessing the effects of the extended duration of left ventricular unloading on cardiac recovery are lacking. An animal model using Impella implanted with a less invasive procedure to enable long-term support is required. This study aimed to evaluate the feasibility of an animal model for long-term support with Impella 5.5 implanted through carotid artery access in sheep.

Impella 5.5 was implanted in four sheep through the proximal region of the left carotid artery without a thoracotomy, and myocardial injuries were induced by coronary microembolization. Support by Impella 5.5 was maintained for 4 weeks, and the animals were observed. The position of Impella 5.5 and cardiac function was evaluated using cardiac computer tomography at 2 and 4 weeks after implantation.

All four animals completed the 4-week study without major complications. The discrepancy in the Impella 5.5 flow rate between the conscious and anesthetized states was observed depending on the device’s position. Animals in whom the inflow was above the left ventricular papillary muscle had a relatively high flow rate under the maximum performance level without a suction alarm during the conscious state. Pathological changes in the aortic valve were observed. Cardiac function under the minimum performance level was observed with no remarkable deterioration.

The animal model with myocardial injuries supported for 4 weeks by Impella 5.5 implanted through carotid artery access in sheep was feasible.

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来源期刊
Journal of Artificial Organs
Journal of Artificial Organs 医学-工程:生物医学
CiteScore
2.80
自引率
15.40%
发文量
68
审稿时长
6-12 weeks
期刊介绍: The aim of the Journal of Artificial Organs is to introduce to colleagues worldwide a broad spectrum of important new achievements in the field of artificial organs, ranging from fundamental research to clinical applications. The scope of the Journal of Artificial Organs encompasses but is not restricted to blood purification, cardiovascular intervention, biomaterials, and artificial metabolic organs. Additionally, the journal will cover technical and industrial innovations. Membership in the Japanese Society for Artificial Organs is not a prerequisite for submission.
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