病毒对癌症发展的作用和影响

IF 17.5 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Periodontology 2000 Pub Date : 2024-04-20 DOI:10.1111/prd.12566

Adolfo Contreras, Sandra Amaya Sánchez, Carolina Rodríguez‐Medina, Javier Enrique Botero

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引用次数: 0

摘要

本综述主要从三个方面探讨肿瘤病毒在癌症发展中的作用。首先，我们讨论了它们的地理分布，揭示了七种肿瘤病毒导致了全球 20% 的人类癌症。其次，我们研究了主要的致癌机制，探讨了这些致癌病毒如何诱导细胞转化、血管生成以及局部和全身炎症。最后，我们研究了 SARS-CoV-2 感染重新激活潜伏肿瘤病毒的可能性，这可能会增加进一步发病的风险。肿瘤病毒疫苗的开发为减轻癌症负担带来了巨大希望。关于导致癌症发生和预防的宿主和环境辅因子，仍有许多未解之谜，目前的研究正试图解决这些问题。

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The role and impact of viruses on cancer development

This review focuses on three major aspects of oncoviruses' role in cancer development. To begin, we discuss their geographic distribution, revealing that seven oncoviruses cause 20% of all human cancers worldwide. Second, we investigate the primary carcinogenic mechanisms, looking at how these oncogenic viruses can induce cellular transformation, angiogenesis, and local and systemic inflammation. Finally, we investigate the possibility of SARS‐CoV‐2 infection reactivating latent oncoviruses, which could increase the risk of further disease. The development of oncovirus vaccines holds great promise for reducing cancer burden. Many unanswered questions about the host and environmental cofactors that contribute to cancer development and prevention remain, which ongoing research is attempting to address.

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来源期刊

Periodontology 2000 医学-牙科与口腔外科

CiteScore

34.10

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Periodontology 2000 is a series of monographs designed for periodontists and general practitioners interested in periodontics. The editorial board selects significant topics and distinguished scientists and clinicians for each monograph. Serving as a valuable supplement to existing periodontal journals, three monographs are published annually, contributing specialized insights to the field.