时间机制：比较神经分化系统的启示

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2024-04-21 DOI:10.1016/j.gde.2024.102197

Chiara Azzi , Teresa Rayon

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引用次数: 0

摘要

时间控制是在发育过程中部署和协调遗传程序的核心。目前，人们对控制发育过程持续时间和速度的分子机制了解有限。时间机制可能并行运行和/或相互影响，以整合整个生物体的时间信号。在这篇文章中，我们将考虑有关发育节奏外在控制的发现，并讨论细胞周期、代谢率、蛋白质周转和转录后机制在神经发育过程中调控节奏的内在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Timing mechanisms: insights from comparative neural differentiation systems

Temporal control is central to deploy and coordinate genetic programs during development. At present, there is limited understanding of the molecular mechanisms that govern the duration and speed of developmental processes. Timing mechanisms may run in parallel and/or interact with each other to integrate temporal signals throughout the organism. In this piece, we consider findings on the extrinsic control of developmental tempo and discuss the intrinsic roles of cell cycle, metabolic rates, protein turnover, and post-transcriptional mechanisms in the regulation of tempo during neural development.

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)