核 mRNA 衰减:控制基因表达的调控网络

IF 39.1 1区 生物学 Q1 GENETICS & HEREDITY
Xavier Rambout, Lynne E. Maquat
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引用次数: 0

摘要

适当调节细胞核中 mRNA 的产生对于在适应内部和环境线索的过程中维持细胞的平衡至关重要。在过去的 25 年中,人们已经清楚地认识到,管理基因转录、前 mRNA 处理、前 mRNA 和 mRNA 衰减以及向细胞质输出 mRNA 的核机制密不可分,它们控制着可用于翻译的 mRNA 的质量和数量。最近,人们发现了核 RNA 衰变因子精细调节编码蛋白质基因表达的新机制,其多样性不断扩大。在这里,我们回顾了目前对哺乳动物细胞如何通过调节细胞核中前 mRNA 和 mRNA 的衰变来塑造其编码蛋白质潜能的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nuclear mRNA decay: regulatory networks that control gene expression

Nuclear mRNA decay: regulatory networks that control gene expression

Nuclear mRNA decay: regulatory networks that control gene expression
Proper regulation of mRNA production in the nucleus is critical for the maintenance of cellular homoeostasis during adaptation to internal and environmental cues. Over the past 25 years, it has become clear that the nuclear machineries governing gene transcription, pre-mRNA processing, pre-mRNA and mRNA decay, and mRNA export to the cytoplasm are inextricably linked to control the quality and quantity of mRNAs available for translation. More recently, an ever-expanding diversity of new mechanisms by which nuclear RNA decay factors finely tune the expression of protein-encoding genes have been uncovered. Here, we review the current understanding of how mammalian cells shape their protein-encoding potential by regulating the decay of pre-mRNAs and mRNAs in the nucleus. In this Review, the authors summarize our current understanding of nuclear pre-mRNA and mRNA decay pathways. They describe how aberrantly processed mRNAs are targeted for decay in the nucleus and how this process is regulated to finely control gene expression.
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来源期刊
Nature Reviews Genetics
Nature Reviews Genetics 生物-遗传学
CiteScore
57.40
自引率
0.50%
发文量
113
审稿时长
6-12 weeks
期刊介绍: At Nature Reviews Genetics, our goal is to be the leading source of reviews and commentaries for the scientific communities we serve. We are dedicated to publishing authoritative articles that are easily accessible to our readers. We believe in enhancing our articles with clear and understandable figures, tables, and other display items. Our aim is to provide an unparalleled service to authors, referees, and readers, and we are committed to maximizing the usefulness and impact of each article we publish. Within our journal, we publish a range of content including Research Highlights, Comments, Reviews, and Perspectives that are relevant to geneticists and genomicists. With our broad scope, we ensure that the articles we publish reach the widest possible audience. As part of the Nature Reviews portfolio of journals, we strive to uphold the high standards and reputation associated with this esteemed collection of publications.
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