溶质载体结构生物学的未来机遇

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-04-18 DOI:10.1038/s41594-024-01271-0

Simon Newstead

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引用次数: 0

摘要

溶质载体（SLC）控制着小分子和离子在生物膜上的流动。过去 20 年来，SLC 生物学研究的步伐明显加快，为治疗代谢疾病、癌症和神经系统疾病带来了新的机遇。最近，在细胞器生物学、代谢物信号转导和贩运方面发挥作用的非典型SLC新家族扩大了它们在细胞中的作用。本透视讨论了导致目前进展的工作，以及靶向和调节 SLCs 以发现新生物学和治疗人类疾病的新机会。在本视角中，作者介绍了在理解溶质运载体（SLC）生物学方面的最新进展，并讨论了非典型SLC新家族的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Future opportunities in solute carrier structural biology

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Future opportunities in solute carrier structural biology

Solute carriers (SLCs) control the flow of small molecules and ions across biological membranes. Over the last 20 years, the pace of research in SLC biology has accelerated markedly, opening new opportunities to treat metabolic diseases, cancer and neurological disorders. Recently, new families of atypical SLCs, with roles in organelle biology, metabolite signaling and trafficking, have expanded their roles in the cell. This Perspective discusses work leading to current advances and the emerging opportunities to target and modulate SLCs to uncover new biology and treat human disease. In this Perspective, the author describes the recent progress in understanding solute carrier (SLC) biology and discusses the roles of new families of atypical SLCs.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.