在酵母和哺乳动物细胞中用亮氨酸错译遗传密码

IF 3.6 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

RNA Biology Pub Date : 2024-04-17 DOI:10.1080/15476286.2024.2340297

Josephine Davey-Young, Farah Hasan, Rasangi Tennakoon, Peter Rozik, Henry Moore, Peter Hall, Ecaterina Cozma, Julie Genereaux, Kyle S. Hoffman, Patricia P. Chan, Todd M. Lowe, Christopher J. Brandl, Patrick O’Donoghue

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引用次数: 0

摘要

翻译的保真度有赖于氨基酰-tRNA 合成酶（AARS）对转移 RNA（tRNA）进行准确的氨基酰化。对丙氨酸 (Ala)、亮氨酸 (Leu)、丝氨酸和吡咯赖氨酸具有特异性的 AARSs 不...

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Mistranslating the genetic code with leucine in yeast and mammalian cells

Translation fidelity relies on accurate aminoacylation of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (AARSs). AARSs specific for alanine (Ala), leucine (Leu), serine, and pyrrolysine do no...

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来源期刊

RNA Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy