女性生殖道小细胞神经内分泌癌:全面概述

IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Pouya Saraei, Abbas Heshmati, Sare Hosseini
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引用次数: 0

摘要

女性生殖道小细胞神经内分泌癌(SCNECs)是一种罕见的侵袭性肿瘤,其特点是复发率高、预后差。它们可发生于女性生殖道的不同部位,包括子宫颈、子宫内膜、卵巢、输卵管、阴道和外阴。它们由具有神经内分泌特征的细胞组成,如能产生和分泌激素和肽,以及高有丝分裂率。对神经内分泌标记物(如嗜铬粒蛋白 A、突触素和 CD56)进行免疫组化染色有助于诊断这些肿瘤。本文概述了这些肿瘤的流行病学、病因学和相关风险因素,以及它们的临床表现、细胞特征、诊断,最后还介绍了目前治疗 SCNECs 的方法,包括手术、化疗和放疗(单独或联合使用)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Small-cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview

Small-cell neuroendocrine carcinomas (SCNECs) of the female genital tract are rare and aggressive tumors that are characterized by a high rate of recurrence and poor prognosis. They can arise from various sites within the female genital tract, including the cervix, endometrium, ovary, fallopian tube, vagina, and vulva. They are composed of cells with neuroendocrine features, such as the ability to produce and secrete hormones and peptides, and a high mitotic rate. Immunohistochemical staining for neuroendocrine markers, such as chromogranin A, synaptophysin, and CD56, can aid in the diagnosis of these tumors. This article provides an overview of the epidemiology, etiology, and risk factors associated with these tumors, as well as their clinical presentation, cellular characteristics, diagnosis, and finally the current treatment options for SCNECs, including surgery, chemotherapy, and radiation therapy, alone or in combination.

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来源期刊
Journal of Neuroendocrinology
Journal of Neuroendocrinology 医学-内分泌学与代谢
CiteScore
6.40
自引率
6.20%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Journal of Neuroendocrinology provides the principal international focus for the newest ideas in classical neuroendocrinology and its expanding interface with the regulation of behavioural, cognitive, developmental, degenerative and metabolic processes. Through the rapid publication of original manuscripts and provocative review articles, it provides essential reading for basic scientists and clinicians researching in this rapidly expanding field. In determining content, the primary considerations are excellence, relevance and novelty. While Journal of Neuroendocrinology reflects the broad scientific and clinical interests of the BSN membership, the editorial team, led by Professor Julian Mercer, ensures that the journal’s ethos, authorship, content and purpose are those expected of a leading international publication.
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