围产期接触交通相关空气污染物与出生后头六个月的感染风险:一项来自中低收入国家的队列研究

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Frida Soesanti, Gerard Hoek, Bert Brunekreef, Kees Meliefste, Jie Chen, Nikmah S. Idris, Nina D. Putri, Cuno S. P. M. Uiterwaal, Diederick E. Grobbee, Kerstin Klipstein-Grobusch
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引用次数: 0

摘要

目的中低收入国家关于围产期暴露于空气污染与婴儿感染风险之间关系的研究非常有限。我们评估了围产期暴露于交通相关空气污染与婴儿出生后 6 个月内感染风险之间的关系。方法:2016 年 3 月至 2020 年 9 月在雅加达对 298 对母婴进行了前瞻性队列研究。采用土地利用回归模型(LUR)对个人水平的 PM2.5、烟尘、氮氧化物和二氧化氮浓度进行了评估。通过重复的访谈调查问卷,获得了婴儿在 1、2、4 和 6 个月大时的感染数据。感染分为上呼吸道感染(流鼻涕、咳嗽、喘息或气短)、下呼吸道感染(肺炎、支气管炎)或胃肠道感染。结果 PM2.5 和二氧化氮的平均浓度远高于世界卫生组织推荐的水平。出生后头六个月中,上呼吸道感染(URTI)比下呼吸道或胃肠道感染更常见(分别为35.6%、3.5%和5.8%)。围产期暴露于PM2.5和烟尘会增加出生后头6个月上呼吸道感染(URTI)的累积风险,每增加一个IQR,调整OR值分别为1.50 (95% CI 0.91; 2.47)和1.14 (95% CI 0.79; 1.64)。煤烟与 4-6 个月大时患尿崩症的风险明显相关(aOR 为 1.45,95%CI 为 1.02;2.09)。所有空气污染物也都与下呼吸道感染呈正相关,但由于样本相对较小,所有 CI 均包含统一值。我们的研究为中低收入国家的婴儿围产期暴露于细颗粒物与呼吸道感染有关提供了更多证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Perinatal exposure to traffic related air pollutants and the risk of infection in the first six months of life: a cohort study from a low-middle income country

Perinatal exposure to traffic related air pollutants and the risk of infection in the first six months of life: a cohort study from a low-middle income country

Objective

There is limited study from low-and-middle income countries on the effect of perinatal exposure to air pollution and the risk of infection in infant. We assessed the association between perinatal exposure to traffic related air pollution and the risk of infection in infant during their first six months of life.

Methods

A prospective cohort study was performed in Jakarta, March 2016–September 2020 among 298 mother-infant pairs. PM2.5, soot, NOx, and NO2 concentrations were assessed using land use regression models (LUR) at individual level. Repeated interviewer-administered questionnaires were used to obtain data on infection at 1, 2, 4 and 6 months of age. The infections were categorized as upper respiratory tract (runny nose, cough, wheezing or shortness of breath), lower respiratory tract (pneumonia, bronchiolitis) or gastrointestinal tract infection. Logistic regression models adjusted for covariates were used to assess the association between perinatal exposure to air pollution and the risk of infection in the first six months of life.

Results

The average concentrations of PM2.5 and NO2 were much higher than the WHO recommended levels. Upper respiratory tract infections (URTI) were much more common in the first six months of life than diagnosed lower respiratory tract or gastro-intestinal infections (35.6%, 3.5% and 5.8% respectively). Perinatal exposure to PM2.5 and soot suggested increase cumulative risk of upper respiratory tract infection (URTI) in the first 6 months of life per IQR increase with adjusted OR of 1.50 (95% CI 0.91; 2.47) and 1.14 (95% CI 0.79; 1.64), respectively. Soot was significantly associated with the risk of URTI at 4–6 months age interval (aOR of 1.45, 95%CI 1.02; 2.09). All air pollutants were also positively associated with lower respiratory tract infection, but all CIs include unity because of relatively small samples. Adjusted odds ratios for gastrointestinal infections were close to unity.

Conclusion

Our study adds to the evidence that perinatal exposure to fine particles is associated with respiratory tract infection in infants in a low-middle income country.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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