手术和非手术治疗后免疫介导的新发血栓性血小板减少性紫癜：系统回顾

IF 6.9 2区医学 Q1 HEMATOLOGY

Blood Reviews Pub Date : 2024-04-09 DOI:10.1016/j.blre.2024.101197

Morgana Pinheiro Maux Lessa , Alexandre Soares Ferreira Junior , Margaret Graton , Erin Simon , Leila Ledbetter , Oluwatoyosi A. Onwuemene

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引用次数: 0

摘要

当在侵入性手术后诊断出新的免疫介导的血栓性血小板减少性紫癜（TTP）时，临床表现模式和预后还不十分明确。因此，我们对在侵入性手术或非手术治疗后被诊断为 TTP 的患者进行了系统性文献回顾，发现有 19 项研究报告了 25 名患者的数据。这些数据表明，TTP 的发病机制很可能在侵入性手术之前就已开始，患者会经历严重的诊断延迟，而且肾脏替代治疗的发生率很高。虽然侵入性手术可能会引发 TTP，但仍需进一步研究以明确这种关联的机制。

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De-novo immune-mediated thrombotic thrombocytopenic purpura following surgical and non-surgical procedures: A systematic review

When de-novo immune-mediated thrombotic thrombocytopenic purpura (TTP) is diagnosed following an invasive procedure, clinical presentation patterns and outcomes are poorly defined. Therefore, in a systematic literature review of patients diagnosed with TTP following an invasive surgical or non-surgical procedure, we identified 19 studies reporting data on 25 patients. These data suggest that 1) TTP pathogenesis likely begins prior to the invasive procedure, 2) patients experience significant diagnostic delays, and 3) there is a high incidence of renal replacement therapy. Although invasive procedures may trigger TTP, further studies are needed to clarify the mechanisms underlying this association.

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来源期刊

Blood Reviews 医学-血液学

CiteScore

13.80

自引率

1.40%

发文量

期刊介绍： Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.