植物生物活性化合物是调节免疫相关疾病的关键因素

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Sara F. Vieira, Rui L. Reis, Helena Ferreira, Nuno M. Neves
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引用次数: 0

摘要

免疫系统是保护生物体的复杂而基本的网络。宿主防御系统平衡的微小失衡都会对人类健康造成严重影响。从根本上说,与免疫有关的疾病可能源于免疫系统受损(免疫缺陷病)、针对自身(自身免疫病)或无害物质(过敏)的过度激活,以及未能消除有害因子(慢性炎症)。在免疫系统疾病病理生理学方面取得的显著进步和成就使现有的治疗方法得到了极大的改进。然而,它们也存在一些缺点,包括效益/风险比不合适。因此,我们亟需开发有效的治疗策略。大自然是生物活性化合物的宝贵来源,可用于开发新药物。特别是,植物可产生种类繁多的次生代谢物,可作为创新治疗药物的潜在原型。本综述介绍了免疫系统和炎症反应,并考察了目前对传统上用作免疫调节药物的八种植物(蛇床子、紫锥菊、月桂、薰衣草、油橄榄、丹参、鼠尾草和蒲公英)的了解。此外,还将讨论可能导致生物读数不一致的问题(植物种类、年龄、所选器官、发育阶段、生长条件、地理位置、干燥方法、储存条件、提取溶剂和提取方法)。此外,还详细列出了所选植物提取物的化学成分和生物活性化合物的免疫调节作用机制。本综述还包括未来展望,并提出了进一步研究的潜在新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Plant-derived bioactive compounds as key players in the modulation of immune-related conditions

Plant-derived bioactive compounds as key players in the modulation of immune-related conditions

The immune system is a complex and fundamental network for organism protection. A minimal unbalance in the host defense system homeostasis can originate severe repercussions in human health. Fundamentally, immune-related diseases can arise from its compromise (immunodeficiency diseases), overactivation against itself (autoimmune diseases) or harmless substances (allergies), and failure of eliminating the harmful agent (chronic inflammation). The notable advances and achievements in the immune system diseases pathophysiology have been allowing for a dramatic improvement of the available treatments. Nevertheless, they present some drawbacks, including the inappropriate benefit/risk ratio. Therefore, there is a strong and urgent need to develop effective therapeutic strategies. Nature is a valuable source of bioactive compounds that can be explored for the development of new drugs. Particularly, plants produce a broad spectrum of secondary metabolites that can be potential prototypes for innovative therapeutic agents. This review describes the immune system and the inflammatory response and examines the current knowledge of eight plants traditionally used as immunomodulatory medicines (Boswellia serrata, Echinacea purpurea, Laurus nobilis, Lavandula angustifolia, Olea europaea, Salvia officinalis, Salvia rosmarinus, and Taraxacum officinale). Moreover, the issues responsible for possible biologic readout inconsistencies (plant species, age, selected organ, developmental stage, growth conditions, geographical location, drying methods, storage conditions, solvent of extraction, and extraction method) will also be discussed. Furthermore, a detailed list of the chemical composition and the immunomodulatory mechanism of action of the bioactive compounds of the selected plant extracts are presented. This review also includes future perspectives and proposes potential new avenues for further investigation.

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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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