{"title":"运动对痴呆症的新启示;体育锻炼和认知锻炼的综合效应","authors":"Hyo-Jeong Cha, Jun Hong Park, Changwan Hong","doi":"10.1007/s13273-024-00440-y","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Dementia is a progressive neurological disorder which is clinically characterized by memory loss, behavioral symptoms, and loss of ability to live a normal life. Dementia patients may have to cope with permanent and irreversible symptoms.</p><h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3><p>Although a new drug for dementia with beta-amyloid-removal function has recently received FDA approval, the effect of delaying the progression of dementia is still insignificant, but the cost is expensive. On the other hand, studies on the effects of exercise in dementia have implied that the incidence of dementia or cognitive decline could be efficiently controlled by exercise.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>The cognitive neuroprotective effect of exercise was supported by cross-sectional studies in which physically fit seniors showed larger hippocampal or gray matter volumes than unfit seniors. In addition, multiple animal studies demonstrate that exercise promotes neuroplasticity through induction of neurotropic factors, with improved outcomes on cognitive functions.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>In this review, we discuss the effects of conventional mode of physical exercise, cognitive (neuromuscular) exercise, and combined exercise in the prevention of dementia, and highlight the prospects for new exercise programs using digital technology that are being recently developed to reduce cognitive decline. Exercise should be importantly considered as a non-pharmacological therapeutic strategy for cognitive decline and dementia.</p>","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"48 1","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New insight of exercise on dementia; combinatory effects of physical and cognitive exercise\",\"authors\":\"Hyo-Jeong Cha, Jun Hong Park, Changwan Hong\",\"doi\":\"10.1007/s13273-024-00440-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Background</h3><p>Dementia is a progressive neurological disorder which is clinically characterized by memory loss, behavioral symptoms, and loss of ability to live a normal life. Dementia patients may have to cope with permanent and irreversible symptoms.</p><h3 data-test=\\\"abstract-sub-heading\\\">Purpose of Review</h3><p>Although a new drug for dementia with beta-amyloid-removal function has recently received FDA approval, the effect of delaying the progression of dementia is still insignificant, but the cost is expensive. On the other hand, studies on the effects of exercise in dementia have implied that the incidence of dementia or cognitive decline could be efficiently controlled by exercise.</p><h3 data-test=\\\"abstract-sub-heading\\\">Recent Findings</h3><p>The cognitive neuroprotective effect of exercise was supported by cross-sectional studies in which physically fit seniors showed larger hippocampal or gray matter volumes than unfit seniors. In addition, multiple animal studies demonstrate that exercise promotes neuroplasticity through induction of neurotropic factors, with improved outcomes on cognitive functions.</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p>In this review, we discuss the effects of conventional mode of physical exercise, cognitive (neuromuscular) exercise, and combined exercise in the prevention of dementia, and highlight the prospects for new exercise programs using digital technology that are being recently developed to reduce cognitive decline. Exercise should be importantly considered as a non-pharmacological therapeutic strategy for cognitive decline and dementia.</p>\",\"PeriodicalId\":18683,\"journal\":{\"name\":\"Molecular & Cellular Toxicology\",\"volume\":\"48 1\",\"pages\":\"\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-04-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular & Cellular Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13273-024-00440-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular & Cellular Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13273-024-00440-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"TOXICOLOGY","Score":null,"Total":0}
New insight of exercise on dementia; combinatory effects of physical and cognitive exercise
Background
Dementia is a progressive neurological disorder which is clinically characterized by memory loss, behavioral symptoms, and loss of ability to live a normal life. Dementia patients may have to cope with permanent and irreversible symptoms.
Purpose of Review
Although a new drug for dementia with beta-amyloid-removal function has recently received FDA approval, the effect of delaying the progression of dementia is still insignificant, but the cost is expensive. On the other hand, studies on the effects of exercise in dementia have implied that the incidence of dementia or cognitive decline could be efficiently controlled by exercise.
Recent Findings
The cognitive neuroprotective effect of exercise was supported by cross-sectional studies in which physically fit seniors showed larger hippocampal or gray matter volumes than unfit seniors. In addition, multiple animal studies demonstrate that exercise promotes neuroplasticity through induction of neurotropic factors, with improved outcomes on cognitive functions.
Conclusion
In this review, we discuss the effects of conventional mode of physical exercise, cognitive (neuromuscular) exercise, and combined exercise in the prevention of dementia, and highlight the prospects for new exercise programs using digital technology that are being recently developed to reduce cognitive decline. Exercise should be importantly considered as a non-pharmacological therapeutic strategy for cognitive decline and dementia.
期刊介绍:
Molecular & Cellular Toxicology publishes original research and reviews in all areas of the complex interaction between the cell´s genome (the sum of all genes within the chromosome), chemicals in the environment, and disease. Acceptable manuscripts are the ones that deal with some topics of environmental contaminants, including those that lie in the domains of analytical chemistry, biochemistry, pharmacology and toxicology with the aspects of molecular and cellular levels. Emphasis will be placed on toxic effects observed at relevant genomics and proteomics, which have direct impact on drug development, environment health, food safety, preventive medicine, and forensic medicine. The journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.