中国老年人中性粒细胞与淋巴细胞比率与全因死亡率的关系:一项回顾性队列研究

IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Fan Li, Yanqin Xiong, Zhitian Zhang, Jiaojiao Liu, Jiangshui Tian, Qiongyue Zhang, Hongmei Yan, Jian Gao
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引用次数: 0

摘要

中性粒细胞与淋巴细胞比值(NLR)是一种新兴的全身炎症标志物,与患者的疾病进展和死亡率有关。然而,关于 NLR 在普通人群中的预测价值的研究十分有限。本研究旨在调查中国老年人群中 NLR 与全因死亡率之间的关系。在 2015 年至 2020 年期间,我们在中国上海的一个社区开展了一项基于健康检查的回顾性队列研究。在 6364 名参与者(年龄≥ 55 岁)中,共有 169 人(2.66%)在中位 5.37 年的随访期间死亡。NLR 中位数为 1.63(四分位数间距:1.29,2.11)。多变量分析显示,NLR 的上 2 个四分位数与全因死亡率呈正相关(Q3 vs Q1:危险比 [HR] = 1.82,95% 置信区间 [CI]:1.07-3.09;Q2 vs Q1:危险比 [HR] = 1.07-3.09;Q3 vs Q1:危险比 [HR] = 1.07-3.09):1.07-3.09; Q4 vs Q1: HR = 2.22, 95% CI: 1.34-3.68, P for trend <.001)。分层和交互分析表明,年龄、性别、体重指数(BMI)、糖尿病史或高血压史不会显著改变 NLR 与全因死亡率之间的关系。在中国老年人群中,NLR升高与全因死亡风险升高独立相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Neutrophil-to-Lymphocyte Ratio With All-Cause Mortality in the Elderly Population in China: A Retrospective Cohort Study
Neutrophil-to-lymphocyte ratio (NLR) is an emerging systemic inflammation marker associated with disease progression and mortality in patients. However, there is limited research on the predictive value of NLR in the general population. This study aimed to investigate the relationship between NLR and all-cause mortality in an elderly Chinese population. A retrospective cohort study was conducted based on health examination in a community in Shanghai, China, between 2015 and 2020. Among 6364 participants (aged ≥ 55 years), a total of 169 (2.66%) participants died during a median follow-up period of 5.37 years. The median NLR was 1.63 (interquartile range: 1.29, 2.11). Multivariate analysis revealed that the upper 2 quartiles of NLR were positively associated with all-cause mortality (Q3 vs Q1: hazard ratio [HR] = 1.82, 95% confidence interval [CI]: 1.07-3.09; Q4 vs Q1: HR = 2.22, 95% CI: 1.34-3.68, P for trend <.001). The stratified and interaction analyses showed that age, sex, body mass index (BMI), history of diabetes, or history of hypertension did not significantly modify the association between NLR and all-cause mortality. Elevated NLR was independently associated with an increased risk of all-cause mortality in the elderly Chinese population.
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来源期刊
Asia-Pacific Journal of Public Health
Asia-Pacific Journal of Public Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.30
自引率
4.00%
发文量
147
审稿时长
6 months
期刊介绍: Asia-Pacific Journal of Public Health (APJPH) is a peer-reviewed, bimonthly journal that focuses on health issues in the Asia-Pacific Region. APJPH publishes original articles on public health related issues, including implications for practical applications to professional education and services for public health and primary health care that are of concern and relevance to the Asia-Pacific region.
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