环境空气污染对小胎儿和大胎儿出生风险的影响:利用日本全国出生数据进行的分析

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Tasuku Okui, Naoki Nakashima
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引用次数: 0

摘要

目的小于胎龄儿(SGA)和大于胎龄儿(LGA)出生是与新生儿健康相关的主要不良出生结果。方法我们使用了日本 2017 年至 2021 年生命统计的出生数据和市级空气污染物数据,包括二氧化氮 (NO2)、二氧化硫 (SO2)、光化学氧化剂和颗粒物 2.5 (PM2.5)。计算了每个新生儿在第一、第二和第三孕期以及整个孕期的环境空气污染水平。采用粗略和调整对数二项式回归模型研究了 SGA/LGA 与环境空气污染水平之间的关系。结果我们分析了 2,434,217 例新生儿的数据。调整后的回归分析表明,无论暴露于哪个时期的二氧化硫水平,SGA 出生与二氧化硫水平之间都存在统计学意义上的显著正相关。具体来说,整个孕期二氧化硫平均值每增加 1 ppb,风险比为 1.014(95% 置信区间 [CI] 1.009,1.019)。此外,使用样条函数进行的回归分析表明,SGA 出生风险比的增加与二氧化硫水平呈线性关系。结论 研究表明,在日本,孕期环境中的二氧化硫水平是导致 SGA 出生的一个风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effects of ambient air pollution on the risk of small- and large-for-gestational-age births: an analysis using national birth data in Japan

Effects of ambient air pollution on the risk of small- and large-for-gestational-age births: an analysis using national birth data in Japan

Objectives

Small-for-gestational-age (SGA) and large-for-gestational-age (LGA) births are major adverse birth outcomes related to newborn health. In contrast, the association between ambient air pollution levels and SGA or LGA births has not been investigated in Japan; hence, the purpose of our study is to investigate this association.

Methods

We used birth data from Vital Statistics in Japan from 2017 to 2021 and municipality-level data on air pollutants, including nitrogen dioxide (NO2), sulfur dioxide (SO2), photochemical oxidants, and particulate matter 2.5 (PM2.5). Ambient air pollution levels throughout the first, second, and third trimesters, as well as the whole pregnancy, were calculated for each birth. The association between SGA/LGA and ambient levels of the air pollutants was investigated using crude and adjusted log-binomial regression models. In addition, a regression model with spline functions was also used to detect the non-linear association.

Results

We analyzed data from 2,434,217 births. Adjusted regression analyses revealed statistically significant and positive associations between SGA birth and SO2 level, regardless of the exposure period. Specifically, the risk ratio for average SO2 values throughout the whole pregnancy was 1.014 (95% confidence interval [CI] 1.009, 1.019) per 1 ppb increase. In addition, regression analysis with spline functions indicated that an increase in risk ratio for SGA birth depending on SO2 level was linear. Furthermore, statistically significant and negative associations were observed between LGA birth and SO2 except for the third trimester.

Conclusions

It was suggested that ambient level of SO2 during the pregnancy term is a risk factor for SGA birth in Japan.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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