具有浆细胞形态的继发性浆细胞白血病（PCL）

IF 0.6 4区医学 Q4 HEMATOLOGY

Journal of Hematopathology Pub Date : 2024-04-06 DOI:10.1007/s12308-024-00583-w

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引用次数: 0

摘要

摘要一名 71 岁女性患者，因 IgA lambda 骨髓瘤复发而出现进行性全血细胞减少。外周血片显示有 5%的泡状细胞。流式细胞术分析显示为浆细胞。骨髓涂片中充满了浆细胞。靶 CD138 细胞 FISH 和分子核型鉴定发现了一个复杂的基因组。NGS 发现了高风险突变。骨髓组织学证实为骨髓瘤，无急性白血病证据。患者被诊断为浆细胞性骨髓瘤进展和继发性 PCL。继发性 PCL 患者预后较差。识别这一亚型并探索新型治疗方法至关重要。

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Secondary plasma cell leukaemia (PCL) with plasmablastic morphology

Abstract

A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts. Target CD138-cell FISH and molecular karyotyping identified a complex genome. NGS identified high-risk mutations. Bone marrow histology confirmed myeloma with no evidence of acute leukaemia. The patient was diagnosed with plasmablastic progression of myeloma and secondary PCL. Secondary PCL patients have a poor prognosis. It is essential to recognize this subtype and explore a novel treatment approach.

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来源期刊

Journal of Hematopathology HEMATOLOGYPATHOLOGY-PATHOLOGY

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Journal of Hematopathology aims at providing pathologists with a special interest in hematopathology with all the information needed to perform modern pathology in evaluating lymphoid tissues and bone marrow. To this end the journal publishes reviews, editorials, comments, original papers, guidelines and protocols, papers on ancillary techniques, and occasional case reports in the fields of the pathology, molecular biology, and clinical features of diseases of the hematopoietic system. The journal is the unique reference point for all pathologists with an interest in hematopathology. Molecular biologists involved in the expanding field of molecular diagnostics and research on lymphomas and leukemia benefit from the journal, too. Furthermore, the journal is of major interest for hematologists dealing with patients suffering from lymphomas, leukemias, and other diseases. The journal is unique in its true international character. Especially in the field of hematopathology it is clear that there are huge geographical variations in incidence of diseases. This is not only locally relevant, but due to globalization, relevant for all those involved in the management of patients.