以三甲基壳聚糖-半胱氨酸为基础的纳米颗粒作为门冬酰胺A的有效递送系统，用于体外和体内肝癌细胞的治疗

IF 4.3 4区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Targeting Pub Date : 2024-04-16 DOI:10.1080/1061186x.2024.2344495

Rui Zou, Yunhe Hao, Chunchun Qi, Xu Peng, Zepeng Huang, Duo Li, Yiyao Wang

引用次数: 0

摘要

马齿苋脑苷脂 A (PCA) 是一种从马齿苋中提取的脑苷脂化合物，已被证实可抑制肝细胞癌（HCC）细胞。本研究旨在探讨马齿苋脑苷脂 A（PCA）对肝癌细胞的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Trimethyl chitosan–cysteine-based nanoparticles as an effective delivery system for portulacerebroside A in the management of hepatocellular carcinoma cells in vitro and in vivo

Portulacerebroside A (PCA), a cerebroside compound extracted from Portulaca oleracea L., has been shown to suppress hepatocellular carcinoma (HCC) cells. This study aims to investigate the effectiv...

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.