骨髓细胞疗法对后肢灌注的影响，系统回顾与荟萃分析。

IF 4 3区医学 Q2 CELL BIOLOGY

Disease Models & Mechanisms Pub Date : 2024-04-15 DOI:10.1242/dmm.050632

F C C van Rhijn-Brouwer, K E Wever, R Kiffen, J R van Rhijn, H Gremmels, J O Fledderus, R W M Vernooij, M C Verhaar

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引用次数: 0

摘要

在临床前研究中，使用骨髓（BM）衍生细胞来恢复灌注显示出良好的效果。然而，慢性肢体缺血（CLTI）的临床研究结果却相互矛盾。我们对临床前研究进行了系统回顾和荟萃分析，以评估骨髓衍生细胞在后肢缺血模型（HLI）中恢复相对灌注的疗效，并确定疗效的可能决定因素。

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The effect of bone marrow derived cell therapies on hind limb perfusion, A systematic review and meta-analysis.

Administration of bone marrow (BM) derived cells to restore perfusion showed promising results in preclinical studies. However, clinical studies in chronic limb threatening ischemia (CLTI) demonstrated conflicting results. We conducted a systematic review and meta-analysis on preclinical studies to assess the efficacy of BM-derived cell administration in restoring relative perfusion in the hind limb ischemia model (HLI) and identify possible determinants of therapeutic efficacy.

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来源期刊

Disease Models & Mechanisms 医学-病理学

CiteScore

6.60

自引率

7.00%

发文量

203

审稿时长

6-12 weeks

期刊介绍： Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.