{"title":"在社区居住的日本成年人中，低血浆 25- 羟维生素 D 水平与高复发性跌倒风险无关：村上队列研究","authors":"Toshi Nishikura, Kaori Kitamura, Yumi Watanabe, Keiko Kabasawa, Toshiko Saito, Akemi Takahashi, Ribeka Takachi, Ryosaku Kobayashi, Rieko Oshiki, Shoichiro Tsugane, Kei Watanabe, Kazutoshi Nakamura","doi":"10.1007/s11657-024-01381-8","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Mini-abstract</h3><p>Reports on the association between vitamin D levels and fall risk have been mixed, and long-term follow-up studies are lacking. This 5-year cohort study of 5,343 community-dwelling Japanese people aged 40–74 years found that low vitamin D levels are not associated with a high risk of recurrent falls.</p><h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Findings of cohort studies on the association between plasma 25-hydoxyvitamin D (25[OH]D) levels and fall risk have been mixed, and long-term follow-up studies are lacking. The present study investigated whether low plasma 25(OH)D levels are longitudinally associated with a high risk of recurrent falls in adults.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This 5-year cohort study included 5,343 community-dwelling Japanese people aged 40–74 years. Baseline blood collection and a questionnaire survey were conducted in 2011–2013. Plasma 25(OH)D levels were determined and divided into quintiles after stratification by season, sex, and age group. Information on recurrent falls occurring in the year before the survey 5 years later was obtained, and participants with two or more falls were considered to have experienced recurrent falls. Covariates were sex, age, marital status, education, occupation, BMI, total physical activity levels, calcium intake, vitamin K intake, smoking, drinking, and disease history.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Mean age and 25(OH)D levels were 60.9 years and 50.9 nmol/L, respectively. In the follow-up survey, 209 recurrent falls were reported. Plasma 25(OH)D levels were not significantly associated with the occurrence of recurrent falls in men, women, or men/women-combined (adjusted P for trend = 0.1198, 0.8383, and 0.2355, respectively). In men and men/women-combined, adjusted ORs for recurrent falls in the lowest quintile were significantly lower (adjusted OR = 0.42 and 0.59, respectively) than the middle quintile (reference).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Low plasma 25(OH)D levels are not associated with a high risk of recurrent falls in middle-aged and older people. Further longitudinal studies will be needed to confirm our findings in other populations.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Low plasma 25-hydroxyvitamin D levels are not associated with a high risk of recurrent falls in community-dwelling Japanese adults: the Murakami cohort study\",\"authors\":\"Toshi Nishikura, Kaori Kitamura, Yumi Watanabe, Keiko Kabasawa, Toshiko Saito, Akemi Takahashi, Ribeka Takachi, Ryosaku Kobayashi, Rieko Oshiki, Shoichiro Tsugane, Kei Watanabe, Kazutoshi Nakamura\",\"doi\":\"10.1007/s11657-024-01381-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Mini-abstract</h3><p>Reports on the association between vitamin D levels and fall risk have been mixed, and long-term follow-up studies are lacking. This 5-year cohort study of 5,343 community-dwelling Japanese people aged 40–74 years found that low vitamin D levels are not associated with a high risk of recurrent falls.</p><h3 data-test=\\\"abstract-sub-heading\\\">Purpose</h3><p>Findings of cohort studies on the association between plasma 25-hydoxyvitamin D (25[OH]D) levels and fall risk have been mixed, and long-term follow-up studies are lacking. The present study investigated whether low plasma 25(OH)D levels are longitudinally associated with a high risk of recurrent falls in adults.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>This 5-year cohort study included 5,343 community-dwelling Japanese people aged 40–74 years. Baseline blood collection and a questionnaire survey were conducted in 2011–2013. Plasma 25(OH)D levels were determined and divided into quintiles after stratification by season, sex, and age group. Information on recurrent falls occurring in the year before the survey 5 years later was obtained, and participants with two or more falls were considered to have experienced recurrent falls. Covariates were sex, age, marital status, education, occupation, BMI, total physical activity levels, calcium intake, vitamin K intake, smoking, drinking, and disease history.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>Mean age and 25(OH)D levels were 60.9 years and 50.9 nmol/L, respectively. In the follow-up survey, 209 recurrent falls were reported. Plasma 25(OH)D levels were not significantly associated with the occurrence of recurrent falls in men, women, or men/women-combined (adjusted P for trend = 0.1198, 0.8383, and 0.2355, respectively). In men and men/women-combined, adjusted ORs for recurrent falls in the lowest quintile were significantly lower (adjusted OR = 0.42 and 0.59, respectively) than the middle quintile (reference).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p>Low plasma 25(OH)D levels are not associated with a high risk of recurrent falls in middle-aged and older people. Further longitudinal studies will be needed to confirm our findings in other populations.</p>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-04-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11657-024-01381-8\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11657-024-01381-8","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
摘要
小摘要有关维生素 D 水平与跌倒风险之间关系的报道不一，而且缺乏长期随访研究。这项对 5343 名 40-74 岁的日本社区居民进行的为期 5 年的队列研究发现，维生素 D 水平低与反复跌倒的高风险无关。本研究调查了低血浆 25(OH)D 水平是否与成人反复跌倒的高风险纵向相关。2011-2013年期间进行了基线采血和问卷调查。按季节、性别和年龄组进行分层后，测定血浆 25(OH)D 水平并将其分为五等分。调查还获得了5年后调查前一年中再次发生跌倒的信息，两次或两次以上跌倒的参与者被视为再次发生跌倒。协变量包括性别、年龄、婚姻状况、教育程度、职业、体重指数、总体力活动量、钙摄入量、维生素 K 摄入量、吸烟、饮酒和疾病史。在随访调查中，共报告了 209 例复发性跌倒。在男性、女性或男性/女性组合中，血浆 25(OH)D 水平与复发性跌倒的发生率无明显关系（调整后的趋势 P 分别为 0.1198、0.8383 和 0.2355）。结论血浆25（OH）D水平低与中老年人复发性跌倒的高风险无关。要在其他人群中证实我们的研究结果，还需要进一步的纵向研究。
Low plasma 25-hydroxyvitamin D levels are not associated with a high risk of recurrent falls in community-dwelling Japanese adults: the Murakami cohort study
Mini-abstract
Reports on the association between vitamin D levels and fall risk have been mixed, and long-term follow-up studies are lacking. This 5-year cohort study of 5,343 community-dwelling Japanese people aged 40–74 years found that low vitamin D levels are not associated with a high risk of recurrent falls.
Purpose
Findings of cohort studies on the association between plasma 25-hydoxyvitamin D (25[OH]D) levels and fall risk have been mixed, and long-term follow-up studies are lacking. The present study investigated whether low plasma 25(OH)D levels are longitudinally associated with a high risk of recurrent falls in adults.
Methods
This 5-year cohort study included 5,343 community-dwelling Japanese people aged 40–74 years. Baseline blood collection and a questionnaire survey were conducted in 2011–2013. Plasma 25(OH)D levels were determined and divided into quintiles after stratification by season, sex, and age group. Information on recurrent falls occurring in the year before the survey 5 years later was obtained, and participants with two or more falls were considered to have experienced recurrent falls. Covariates were sex, age, marital status, education, occupation, BMI, total physical activity levels, calcium intake, vitamin K intake, smoking, drinking, and disease history.
Results
Mean age and 25(OH)D levels were 60.9 years and 50.9 nmol/L, respectively. In the follow-up survey, 209 recurrent falls were reported. Plasma 25(OH)D levels were not significantly associated with the occurrence of recurrent falls in men, women, or men/women-combined (adjusted P for trend = 0.1198, 0.8383, and 0.2355, respectively). In men and men/women-combined, adjusted ORs for recurrent falls in the lowest quintile were significantly lower (adjusted OR = 0.42 and 0.59, respectively) than the middle quintile (reference).
Conclusion
Low plasma 25(OH)D levels are not associated with a high risk of recurrent falls in middle-aged and older people. Further longitudinal studies will be needed to confirm our findings in other populations.
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