Ali Majlesara, Ehsan Aminizadeh, Ali Ramouz, Elias Khajeh, Mohammadamin Shahrbaf, Filipe Borges, Gil Goncalves, Carlos Carvalho, Mohammad Golriz, Arianeb Mehrabi
{"title":"评估肝胆外科随机对照试验的质量和数量：范围/绘图回顾","authors":"Ali Majlesara, Ehsan Aminizadeh, Ali Ramouz, Elias Khajeh, Mohammadamin Shahrbaf, Filipe Borges, Gil Goncalves, Carlos Carvalho, Mohammad Golriz, Arianeb Mehrabi","doi":"10.1111/eci.14210","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>To evaluate the quantity and quality of randomized controlled trials (RCTs) in hepatobiliary surgery and for identifying gaps in current evidences.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A systematic search was conducted in MEDLINE (via PubMed), Web of Science, and Cochrane Controlled Register of Trials (CENTRAL) for RCTs of hepatobiliary surgery published from inception until the end of 2023. The quality of each study was assessed using the Cochrane risk-of-bias (RoB) tool. The associations between risk of bias and the region and publication date were also assessed. Evidence mapping was performed to identify research gaps in the field.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The study included 1187 records. The number and proportion of published randomized controlled trials (RCTs) in hepatobiliary surgery increased over time, from 13 RCTs (.0005% of publications) in 1970–1979 to 201 RCTs (.003% of publications) in 2020–2023. There was a significant increase in the number of studies with a low risk of bias in RoB domains (<i>p</i> < .01). The proportion of RCTs with low risk of bias improved significantly after the introduction of CONSORT guidelines (<i>p</i> < .001). The evidence mapping revealed a significant research focus on major and minor hepatectomy and cholecystectomy. However, gaps were identified in liver cyst surgery and hepatobiliary vascular surgery. Additionally, there are gaps in the field of perioperative management and nutrition intervention.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The quantity and quality of RCTs in hepatobiliary surgery have increased over time, but there is still room for improvement. We have identified gaps in current research that can be addressed in future studies.</p>\n </section>\n </div>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of quality and quantity of randomized controlled trials in hepatobiliary surgery: A scoping/mapping review\",\"authors\":\"Ali Majlesara, Ehsan Aminizadeh, Ali Ramouz, Elias Khajeh, Mohammadamin Shahrbaf, Filipe Borges, Gil Goncalves, Carlos Carvalho, Mohammad Golriz, Arianeb Mehrabi\",\"doi\":\"10.1111/eci.14210\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>To evaluate the quantity and quality of randomized controlled trials (RCTs) in hepatobiliary surgery and for identifying gaps in current evidences.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A systematic search was conducted in MEDLINE (via PubMed), Web of Science, and Cochrane Controlled Register of Trials (CENTRAL) for RCTs of hepatobiliary surgery published from inception until the end of 2023. The quality of each study was assessed using the Cochrane risk-of-bias (RoB) tool. The associations between risk of bias and the region and publication date were also assessed. Evidence mapping was performed to identify research gaps in the field.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The study included 1187 records. The number and proportion of published randomized controlled trials (RCTs) in hepatobiliary surgery increased over time, from 13 RCTs (.0005% of publications) in 1970–1979 to 201 RCTs (.003% of publications) in 2020–2023. There was a significant increase in the number of studies with a low risk of bias in RoB domains (<i>p</i> < .01). The proportion of RCTs with low risk of bias improved significantly after the introduction of CONSORT guidelines (<i>p</i> < .001). The evidence mapping revealed a significant research focus on major and minor hepatectomy and cholecystectomy. 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Evaluation of quality and quantity of randomized controlled trials in hepatobiliary surgery: A scoping/mapping review
Aim
To evaluate the quantity and quality of randomized controlled trials (RCTs) in hepatobiliary surgery and for identifying gaps in current evidences.
Methods
A systematic search was conducted in MEDLINE (via PubMed), Web of Science, and Cochrane Controlled Register of Trials (CENTRAL) for RCTs of hepatobiliary surgery published from inception until the end of 2023. The quality of each study was assessed using the Cochrane risk-of-bias (RoB) tool. The associations between risk of bias and the region and publication date were also assessed. Evidence mapping was performed to identify research gaps in the field.
Results
The study included 1187 records. The number and proportion of published randomized controlled trials (RCTs) in hepatobiliary surgery increased over time, from 13 RCTs (.0005% of publications) in 1970–1979 to 201 RCTs (.003% of publications) in 2020–2023. There was a significant increase in the number of studies with a low risk of bias in RoB domains (p < .01). The proportion of RCTs with low risk of bias improved significantly after the introduction of CONSORT guidelines (p < .001). The evidence mapping revealed a significant research focus on major and minor hepatectomy and cholecystectomy. However, gaps were identified in liver cyst surgery and hepatobiliary vascular surgery. Additionally, there are gaps in the field of perioperative management and nutrition intervention.
Conclusion
The quantity and quality of RCTs in hepatobiliary surgery have increased over time, but there is still room for improvement. We have identified gaps in current research that can be addressed in future studies.
期刊介绍：
EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.
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