Tobias Schupp, Kathrin Weidner, Marielen Reinhardt, Noah Abel, Alexander Schmitt, Felix Lau, Maximilian Kittel, Thomas Bertsch, Christel Weiß, Michael Behnes, Ibrahim Akin
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Patients with anaemia (i.e. haemoglobin <13 g/dL in males and < 12 g/dL in females) were compared to patients without, respectively patients with or without iron deficiency. The primary endpoint was all-cause mortality at 30 months (median follow-up), secondary endpoints comprised HF-related rehospitalisation.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Two thousand one hundred and fifty four patients with HFmrEF with a median haemoglobin level of 12.2 g/dL were included. Anaemia was present in 52% of patients with HFmrEF and associated with a higher risk of all-cause mortality (44% vs. 18%; HR = 3.021; 95% CI 2.552–3.576; <i>p</i> =.001) and HF-related rehospitalisation (18% vs. 8%; HR = 2.351; 95% CI 1.819–3.040; <i>p</i> =.001) at 30 months, which was confirmed after multivariable adjustment. Although iron status was infrequently assessed in anaemics with HFmrEF (27%), the presence of iron deficiency was associated with higher risk of rehospitalisation for worsening HF (25% vs. 15%; HR = 1.746; 95% CI 1.024–2.976; <i>p</i> =.038), but not all-cause mortality (<i>p</i> =.279) at 30 months.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Anaemia and iron deficiency are very common in atleast half of patients with HFmrEF and independently associated with adverse long-term prognosis.</p>\n </section>\n </div>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of anaemia and iron deficiency in heart failure with mildly reduced ejection fraction\",\"authors\":\"Tobias Schupp, Kathrin Weidner, Marielen Reinhardt, Noah Abel, Alexander Schmitt, Felix Lau, Maximilian Kittel, Thomas Bertsch, Christel Weiß, Michael Behnes, Ibrahim Akin\",\"doi\":\"10.1111/eci.14205\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>The present study aims to clarify the prevalence and prognostic impact of anaemia and iron deficiency in patients with heart failure with mildly reduced ejection fraction (HFmrEF).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>The prognostic impact of anaemia and iron deficiency in HFmrEF has not yet been clarified.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. 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引用次数: 0
摘要
本研究旨在明确射血分数轻度降低的心力衰竭（HFmrEF）患者中贫血和缺铁的患病率及其对预后的影响。方法回顾性纳入一家机构从2016年至2022年连续收治的HFmrEF患者。将贫血患者（即男性血红蛋白为 13 g/dL，女性为 12 g/dL）与非贫血患者、缺铁或不缺铁患者进行比较。主要终点是 30 个月（中位数随访）的全因死亡率，次要终点包括与心房颤动相关的再住院。52%的高频低氧血症患者存在贫血，30个月后，贫血与较高的全因死亡风险（44% vs. 18%；HR = 3.021；95% CI 2.552-3.576；p =.001）和高频相关再住院风险（18% vs. 8%；HR = 2.351；95% CI 1.819-3.040；p =.001）相关，多变量调整后证实了这一点。虽然铁质状况在 HFmrEF 患者中很少得到评估（27%），但缺铁与 30 个月后因 HF 恶化而再次入院的风险较高（25% vs. 15%；HR = 1.746；95% CI 1.024-2.976；p =.038）有关，但与全因死亡率无关（p =.279）。
Effect of anaemia and iron deficiency in heart failure with mildly reduced ejection fraction
Objective
The present study aims to clarify the prevalence and prognostic impact of anaemia and iron deficiency in patients with heart failure with mildly reduced ejection fraction (HFmrEF).
Background
The prognostic impact of anaemia and iron deficiency in HFmrEF has not yet been clarified.
Methods
Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with anaemia (i.e. haemoglobin <13 g/dL in males and < 12 g/dL in females) were compared to patients without, respectively patients with or without iron deficiency. The primary endpoint was all-cause mortality at 30 months (median follow-up), secondary endpoints comprised HF-related rehospitalisation.
Results
Two thousand one hundred and fifty four patients with HFmrEF with a median haemoglobin level of 12.2 g/dL were included. Anaemia was present in 52% of patients with HFmrEF and associated with a higher risk of all-cause mortality (44% vs. 18%; HR = 3.021; 95% CI 2.552–3.576; p =.001) and HF-related rehospitalisation (18% vs. 8%; HR = 2.351; 95% CI 1.819–3.040; p =.001) at 30 months, which was confirmed after multivariable adjustment. Although iron status was infrequently assessed in anaemics with HFmrEF (27%), the presence of iron deficiency was associated with higher risk of rehospitalisation for worsening HF (25% vs. 15%; HR = 1.746; 95% CI 1.024–2.976; p =.038), but not all-cause mortality (p =.279) at 30 months.
Conclusion
Anaemia and iron deficiency are very common in atleast half of patients with HFmrEF and independently associated with adverse long-term prognosis.
期刊介绍：
EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.
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