轴突近端驱动蛋白的调控对树突选择性运输至关重要

IF 3.1 3区生物学 Q3 CELL BIOLOGY

Molecular Biology of the Cell Pub Date : 2024-04-10 DOI:10.1091/mbc.e23-11-0457

Christina S. Mendoza, Cameron R. Plowinske, Andrew C. Montgomery, Geraldine B. Quinones, Gary Banker, Marvin Bentley

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引用次数: 0

摘要

作者定义了一个新的分子模型，即驱动蛋白-3 家族成员 KIF13A 通过 MARK2 介导的近端轴突磷酸化调控。这些结果表明，驱动蛋白与树突小泡结合的调控，而不是小泡捕获，是终止轴突基部树突选择性小泡前向运输的关键调控事件。

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Kinesin Regulation in the Proximal Axon is Essential for Dendrite-selective Transport

Dendritic polarity is maintained by the arrest of dendrite-selective vesicles in the proximal axon, but the mechanism that mediates this arrest is unknown.
The authors define a new molecular model of kinesin-3 family member KIF13A regulation by MARK2-mediated phosphorylation in the proximal axon. KIF13A is then recognized by 14-3-3 family members, resulting in kinesin-vesicle dissociation and termination of anterograde transport.
These results indicate that regulation of kinesin binding to dendritic vesicles, rather than vesicle capture, is the key regulatory event that terminates anterograde transport of dendrite-selective vesicles at the base of the axon.

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来源期刊

Molecular Biology of the Cell 生物-细胞生物学

CiteScore

6.00

自引率

6.10%

发文量

402

审稿时长

2 months

期刊介绍： MBoC publishes research articles that present conceptual advances of broad interest and significance within all areas of cell, molecular, and developmental biology. We welcome manuscripts that describe advances with applications across topics including but not limited to: cell growth and division; nuclear and cytoskeletal processes; membrane trafficking and autophagy; organelle biology; quantitative cell biology; physical cell biology and mechanobiology; cell signaling; stem cell biology and development; cancer biology; cellular immunology and microbial pathogenesis; cellular neurobiology; prokaryotic cell biology; and cell biology of disease.