{"title":"抗血栓药物在不同年龄段上消化道出血患者中的应用","authors":"Ding Peng, Huihong Zhai","doi":"10.1155/2024/1710708","DOIUrl":null,"url":null,"abstract":"<i>Objective</i>. This study aimed at exploring the safety and timing of antithrombotic drugs in different age-group patients with UGIB. <i>Methods</i>. An observational study retrospectively based on the single-center database with 713 patients with UGIB. <i>Result</i>. Among the 713 patients, 62.13% were elderly patients (<span><svg height=\"12.7112pt\" style=\"vertical-align:-3.403299pt\" version=\"1.1\" viewbox=\"-0.0498162 -9.3079 35.429 12.7112\" width=\"35.429pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,5.642,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,11.621,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,17.212,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,27.798,0)\"></path></g></svg><span></span><svg height=\"12.7112pt\" style=\"vertical-align:-3.403299pt\" version=\"1.1\" viewbox=\"39.0111838 -9.3079 12.655 12.7112\" width=\"12.655pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,39.061,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,45.301,0)\"></path></g></svg></span> years) and the mortality was 2.9%. In elderly patients with UGIB, we found that previous medication history, resumption of medication, and time of resumption did not affect the in-hospital mortality. The resumption of anticoagulants increased the risk of rebleeding. The independent risk factors of mortality were CHF, cirrhosis, creatine kinase, and albumin. The independent risk factors of rebleeding were the application of anticoagulants during hospitalization, variceal bleeding, black stool, red blood cells (lab), platelets (lab), and heart rate. <i>Conclusions</i>. In UGIB patients, a history of antiplatelet or antithrombotic drugs and the use of antiplatelet drugs after UGIB did not affect the patient’s prognosis. In elderly UGIB patients, although antithrombotic drugs did not increase the risk of death, the increased risk of rebleeding after resumption of use deserved careful treatment. It was safe to recover anticoagulant drugs as soon as possible in young UGIB patients.","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"49 1","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application of Antithrombotic Drugs in Different Age-Group Patients with Upper Gastrointestinal Bleeding\",\"authors\":\"Ding Peng, Huihong Zhai\",\"doi\":\"10.1155/2024/1710708\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<i>Objective</i>. This study aimed at exploring the safety and timing of antithrombotic drugs in different age-group patients with UGIB. <i>Methods</i>. An observational study retrospectively based on the single-center database with 713 patients with UGIB. <i>Result</i>. Among the 713 patients, 62.13% were elderly patients (<span><svg height=\\\"12.7112pt\\\" style=\\\"vertical-align:-3.403299pt\\\" version=\\\"1.1\\\" viewbox=\\\"-0.0498162 -9.3079 35.429 12.7112\\\" width=\\\"35.429pt\\\" xmlns=\\\"http://www.w3.org/2000/svg\\\" xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\"><g transform=\\\"matrix(.013,0,0,-0.013,0,0)\\\"></path></g><g transform=\\\"matrix(.013,0,0,-0.013,5.642,0)\\\"></path></g><g transform=\\\"matrix(.013,0,0,-0.013,11.621,0)\\\"></path></g><g transform=\\\"matrix(.013,0,0,-0.013,17.212,0)\\\"></path></g><g transform=\\\"matrix(.013,0,0,-0.013,27.798,0)\\\"></path></g></svg><span></span><svg height=\\\"12.7112pt\\\" style=\\\"vertical-align:-3.403299pt\\\" version=\\\"1.1\\\" viewbox=\\\"39.0111838 -9.3079 12.655 12.7112\\\" width=\\\"12.655pt\\\" xmlns=\\\"http://www.w3.org/2000/svg\\\" xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\"><g transform=\\\"matrix(.013,0,0,-0.013,39.061,0)\\\"></path></g><g transform=\\\"matrix(.013,0,0,-0.013,45.301,0)\\\"></path></g></svg></span> years) and the mortality was 2.9%. In elderly patients with UGIB, we found that previous medication history, resumption of medication, and time of resumption did not affect the in-hospital mortality. The resumption of anticoagulants increased the risk of rebleeding. The independent risk factors of mortality were CHF, cirrhosis, creatine kinase, and albumin. The independent risk factors of rebleeding were the application of anticoagulants during hospitalization, variceal bleeding, black stool, red blood cells (lab), platelets (lab), and heart rate. <i>Conclusions</i>. In UGIB patients, a history of antiplatelet or antithrombotic drugs and the use of antiplatelet drugs after UGIB did not affect the patient’s prognosis. In elderly UGIB patients, although antithrombotic drugs did not increase the risk of death, the increased risk of rebleeding after resumption of use deserved careful treatment. It was safe to recover anticoagulant drugs as soon as possible in young UGIB patients.\",\"PeriodicalId\":12597,\"journal\":{\"name\":\"Gastroenterology Research and Practice\",\"volume\":\"49 1\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gastroenterology Research and Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2024/1710708\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastroenterology Research and Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2024/1710708","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Application of Antithrombotic Drugs in Different Age-Group Patients with Upper Gastrointestinal Bleeding
Objective. This study aimed at exploring the safety and timing of antithrombotic drugs in different age-group patients with UGIB. Methods. An observational study retrospectively based on the single-center database with 713 patients with UGIB. Result. Among the 713 patients, 62.13% were elderly patients ( years) and the mortality was 2.9%. In elderly patients with UGIB, we found that previous medication history, resumption of medication, and time of resumption did not affect the in-hospital mortality. The resumption of anticoagulants increased the risk of rebleeding. The independent risk factors of mortality were CHF, cirrhosis, creatine kinase, and albumin. The independent risk factors of rebleeding were the application of anticoagulants during hospitalization, variceal bleeding, black stool, red blood cells (lab), platelets (lab), and heart rate. Conclusions. In UGIB patients, a history of antiplatelet or antithrombotic drugs and the use of antiplatelet drugs after UGIB did not affect the patient’s prognosis. In elderly UGIB patients, although antithrombotic drugs did not increase the risk of death, the increased risk of rebleeding after resumption of use deserved careful treatment. It was safe to recover anticoagulant drugs as soon as possible in young UGIB patients.
期刊介绍:
Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders.
Topics of interest include:
Management of pancreatic diseases
Third space endoscopy
Endoscopic resection
Therapeutic endoscopy
Therapeutic endosonography.