全基因组关联研究发现苏淮猪消化道性状的五个数量性状位点和两个候选基因

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-15 DOI:10.1111/age.13430

Kaijun Li, Liming Hou, Taoran Du, Guang Pu, Chenxi Liu, Gensheng Liu, Juan Zhou, Ruihua Huang, Qingbo Zhao, Pinghua Li

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引用次数: 0

摘要

这项工作旨在确定猪消化道性状的标记和候选基因。通过 80 个 K 芯片数据或 50 个 K 芯片数据对 331 头猪进行了基因分型。在表观中性洗涤纤维消化率方面，利用全基因组高效混合模型关联算法和关联-异平衡调整亲缘关系，分别鉴定出了19个和21个候选单核苷酸多态性（SNP）。其中，确定了三个数量性状基因座（QTL）区域。在表观酸性洗涤纤维消化率方面，这两种方法分别鉴定出了 16 个和 17 个 SNPs。其中，还确定了三个 QTL 区域。此外，在这些显著的 SNP 附近还发现了两个候选基因（MST1 和 LATS1），它们在功能上与肠道平衡和健康有关。综上所述，我们的研究结果可为深入研究猪的消化道性状提供依据。

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Genome-wide association study identified five quantitative trait loci and two candidate genes for digestive traits in Suhuai pigs

This work aimed to identify markers and candidate genes underlying porcine digestive traits. In total, 331 pigs were genotyped by 80 K Chip data or 50 K Chip data. For apparent neutral detergent fiber digestibility, a total of 19 and 21 candidate single nucleotide polymorphisms (SNP) were respectively identified using a genome-wide efficient mixed-model association algorithm and linkage-disequilibrium adjusted kinship. Among them, three quantitative trait locus (QTL) regions were identified. For apparent acid detergent fiber digestibility, a total of 16 and 17 SNPs were identified by these two methods, respectively. Of these, three QTL regions were also identified. Moreover, two candidate genes (MST1 and LATS1), which are functionally related to intestinal homeostasis and health, were detected near these significant SNPs. Taken together, our results could provide a basis for deeper research on digestive traits in pigs.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.