Kaijun Li, Liming Hou, Taoran Du, Guang Pu, Chenxi Liu, Gensheng Liu, Juan Zhou, Ruihua Huang, Qingbo Zhao, Pinghua Li
{"title":"全基因组关联研究发现苏淮猪消化道性状的五个数量性状位点和两个候选基因","authors":"Kaijun Li, Liming Hou, Taoran Du, Guang Pu, Chenxi Liu, Gensheng Liu, Juan Zhou, Ruihua Huang, Qingbo Zhao, Pinghua Li","doi":"10.1111/age.13430","DOIUrl":null,"url":null,"abstract":"<p>This work aimed to identify markers and candidate genes underlying porcine digestive traits. In total, 331 pigs were genotyped by 80 K Chip data or 50 K Chip data. For apparent neutral detergent fiber digestibility, a total of 19 and 21 candidate single nucleotide polymorphisms (SNP) were respectively identified using a genome-wide efficient mixed-model association algorithm and linkage-disequilibrium adjusted kinship. Among them, three quantitative trait locus (QTL) regions were identified. For apparent acid detergent fiber digestibility, a total of 16 and 17 SNPs were identified by these two methods, respectively. Of these, three QTL regions were also identified. Moreover, two candidate genes (<i>MST1</i> and <i>LATS1</i>), which are functionally related to intestinal homeostasis and health, were detected near these significant SNPs. Taken together, our results could provide a basis for deeper research on digestive traits in pigs.</p>","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"55 3","pages":"471-474"},"PeriodicalIF":1.8000,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genome-wide association study identified five quantitative trait loci and two candidate genes for digestive traits in Suhuai pigs\",\"authors\":\"Kaijun Li, Liming Hou, Taoran Du, Guang Pu, Chenxi Liu, Gensheng Liu, Juan Zhou, Ruihua Huang, Qingbo Zhao, Pinghua Li\",\"doi\":\"10.1111/age.13430\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This work aimed to identify markers and candidate genes underlying porcine digestive traits. In total, 331 pigs were genotyped by 80 K Chip data or 50 K Chip data. For apparent neutral detergent fiber digestibility, a total of 19 and 21 candidate single nucleotide polymorphisms (SNP) were respectively identified using a genome-wide efficient mixed-model association algorithm and linkage-disequilibrium adjusted kinship. Among them, three quantitative trait locus (QTL) regions were identified. For apparent acid detergent fiber digestibility, a total of 16 and 17 SNPs were identified by these two methods, respectively. Of these, three QTL regions were also identified. Moreover, two candidate genes (<i>MST1</i> and <i>LATS1</i>), which are functionally related to intestinal homeostasis and health, were detected near these significant SNPs. Taken together, our results could provide a basis for deeper research on digestive traits in pigs.</p>\",\"PeriodicalId\":7905,\"journal\":{\"name\":\"Animal genetics\",\"volume\":\"55 3\",\"pages\":\"471-474\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Animal genetics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/age.13430\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal genetics","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/age.13430","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 0
摘要
这项工作旨在确定猪消化道性状的标记和候选基因。通过 80 个 K 芯片数据或 50 个 K 芯片数据对 331 头猪进行了基因分型。在表观中性洗涤纤维消化率方面，利用全基因组高效混合模型关联算法和关联-异平衡调整亲缘关系，分别鉴定出了19个和21个候选单核苷酸多态性（SNP）。其中，确定了三个数量性状基因座（QTL）区域。在表观酸性洗涤纤维消化率方面，这两种方法分别鉴定出了 16 个和 17 个 SNPs。其中，还确定了三个 QTL 区域。此外，在这些显著的 SNP 附近还发现了两个候选基因（MST1 和 LATS1），它们在功能上与肠道平衡和健康有关。综上所述，我们的研究结果可为深入研究猪的消化道性状提供依据。
Genome-wide association study identified five quantitative trait loci and two candidate genes for digestive traits in Suhuai pigs
This work aimed to identify markers and candidate genes underlying porcine digestive traits. In total, 331 pigs were genotyped by 80 K Chip data or 50 K Chip data. For apparent neutral detergent fiber digestibility, a total of 19 and 21 candidate single nucleotide polymorphisms (SNP) were respectively identified using a genome-wide efficient mixed-model association algorithm and linkage-disequilibrium adjusted kinship. Among them, three quantitative trait locus (QTL) regions were identified. For apparent acid detergent fiber digestibility, a total of 16 and 17 SNPs were identified by these two methods, respectively. Of these, three QTL regions were also identified. Moreover, two candidate genes (MST1 and LATS1), which are functionally related to intestinal homeostasis and health, were detected near these significant SNPs. Taken together, our results could provide a basis for deeper research on digestive traits in pigs.
期刊介绍：
Animal Genetics reports frontline research on immunogenetics, molecular genetics and functional genomics of economically important and domesticated animals. Publications include the study of variability at gene and protein levels, mapping of genes, traits and QTLs, associations between genes and traits, genetic diversity, and characterization of gene or protein expression and control related to phenotypic or genetic variation.
The journal publishes full-length articles, short communications and brief notes, as well as commissioned and submitted mini-reviews on issues of interest to Animal Genetics readers.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
