Alodia Lacueva-Aparicio, Viviana Jehová González, Ana Rosa Remacha, Daniel Woods, Eduardo Prado, Ignacio Ochoa, Sara Oliván and Ester Vázquez
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引用次数: 0
摘要
近几十年来,由于纳米技术在许多工业和生物医学领域的广泛应用,该领域发展迅速。值得注意的是,石墨烯相关材料(GRMs)等二维材料已被广泛探索,因此需要对其安全性进行评估。然而,石墨烯相关材料往往沉积迅速,在水溶液中稳定性低,而且会吸附在塑料材料上。因此,基于静态检测的传统方法会促进其沉积和吸附,无法再现人体生理状况。然而,芯片上器官(OOC)技术可以解决这些弊端,开发出模拟人体组织微环境的微生理系统(MPS)。有鉴于此,本研究对流动条件下的微流体系统进行了优化,以尽量减少氧化石墨烯(GO)和少层石墨烯(FLG)的吸附和沉积。为此,开发并优化了芯片肾,以评估在流体流动条件下接触亚致死剂量的 GO 和 FLG 片的影响。总之,MPS 是一种创新而精确的工具,可用于评估接触 GRMs 和其他类型纳米材料的影响。
A microphysiological system for handling graphene related materials under flow conditions†
The field of nanotechnology has developed rapidly in recent decades due to its broad applications in many industrial and biomedical fields. Notably, 2D materials such as graphene-related materials (GRMs) have been extensively explored and, as such, their safety needs to be assessed. However, GRMs tend to deposit quickly, present low stability in aqueous solutions, and adsorb to plastic materials. Consequently, traditional approaches based on static assays facilitate their deposition and adsorption and fail to recreate human physiological conditions. Organ-on-a-chip (OOC) technology could, however, solve these drawbacks and lead to the development of microphysiological systems (MPSs) that mimic the microenvironment present in human tissues. In light of the above, in the present study a microfluidic system under flow conditions has been optimised to minimise graphene oxide (GO) and few-layer graphene (FLG) adsorption and deposition. For that purpose, a kidney-on-a-chip was developed and optimised to evaluate the effects of exposure to GO and FLG flakes at a sublethal dose under fluid flow conditions. In summary, MPSs are an innovative and precise tool for evaluating the effects of exposure to GRMs and other type of nanomaterials.
期刊介绍:
Nanoscale Horizons stands out as a premier journal for publishing exceptionally high-quality and innovative nanoscience and nanotechnology. The emphasis lies on original research that introduces a new concept or a novel perspective (a conceptual advance), prioritizing this over reporting technological improvements. Nevertheless, outstanding articles showcasing truly groundbreaking developments, including record-breaking performance, may also find a place in the journal. Published work must be of substantial general interest to our broad and diverse readership across the nanoscience and nanotechnology community.