Yeqin Li, Yan Zhang, Liwen Tian, Ju Li, Huihua Li, Ximing Wang, Cuiyan Wang
{"title":"三维酰胺质子转移加权成像可用于诊断早期乳腺癌：一项前瞻性单中心研究","authors":"Yeqin Li, Yan Zhang, Liwen Tian, Ju Li, Huihua Li, Ximing Wang, Cuiyan Wang","doi":"10.1186/s41747-024-00439-z","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>We investigated the value of three-dimensional amide proton transfer-weighted imaging (3D-APTWI) in the diagnosis of early-stage breast cancer (BC) and its correlation with the immunohistochemical characteristics of malignant lesions.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Seventy-eight women underwent APTWI and dynamic contrast-enhanced (DCE)-MRI. Pathological results were categorized as either benign (<i>n</i> = 43) or malignant (<i>n</i> = 37) lesions. The parameters of APTWI and DCE-MRI were compared between the benign and malignant groups. The diagnostic value of 3D-APTWI was evaluated using the area under the receiver operating characteristic curve (ROC-AUC) to establish a diagnostic threshold. Pearson’s correlation was used to analyze the correlation between the magnetization transfer asymmetry (MTR<sub>asym</sub>) and immunohistochemical characteristics.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The MTR<sub>asym</sub> and time-to-peak of malignancies were significantly lower than those of benign lesions (all <i>p</i> < 0.010). The volume transfer constant, rate constant, and wash-in and wash-out rates of malignancies were all significantly greater than those of benign lesions (all <i>p</i> < 0.010). ROC-AUCs of 3D-APTWI, DCE-MRI, and 3D-APTWI+DCE to differential diagnosis between early-stage BC and benign lesions were 0.816, 0.745, and 0.858, respectively. Only the difference between AUC<sub>APT+DCE</sub> and AUC<sub>DCE</sub> was significant (<i>p</i> < 0.010). When a threshold of MTR<sub>asym</sub> for malignancy for 2.42%, the sensitivity and specificity of 3D-APTWI for BC diagnosis were 86.5% and 67.6%, respectively; MTR<sub>asym</sub> was modestly positively correlated with pathological grade (<i>r</i> = 0.476, <i>p</i> = 0.003) and Ki-67 (<i>r</i> = 0.419, <i>p</i> = 0.020).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>3D-APTWI may be used as a supplementary method for patients with contraindications of DCE-MRI. MTR<sub>asym</sub> can imply the proliferation activities of early-stage BC.</p><h3 data-test=\"abstract-sub-heading\">Relevance statement</h3><p>3D-APTWI can be an alternative diagnostic method for patients with early-stage BC who are not suitable for contrast injection.</p><h3 data-test=\"abstract-sub-heading\">Key points</h3><p>• 3D-APTWI reflects the changes in the microenvironment of early-stage breast cancer.</p><p>• Combined 3D-APTWI is superior to DCE-MRI alone for early-stage breast cancer diagnosis.</p><p>• 3D-APTWI improves the diagnostic accuracy of early-stage breast cancer.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\n","PeriodicalId":36926,"journal":{"name":"European Radiology Experimental","volume":"268 1","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"3D amide proton transfer-weighted imaging may be useful for diagnosing early-stage breast cancer: a prospective monocentric study\",\"authors\":\"Yeqin Li, Yan Zhang, Liwen Tian, Ju Li, Huihua Li, Ximing Wang, Cuiyan Wang\",\"doi\":\"10.1186/s41747-024-00439-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Background</h3><p>We investigated the value of three-dimensional amide proton transfer-weighted imaging (3D-APTWI) in the diagnosis of early-stage breast cancer (BC) and its correlation with the immunohistochemical characteristics of malignant lesions.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>Seventy-eight women underwent APTWI and dynamic contrast-enhanced (DCE)-MRI. Pathological results were categorized as either benign (<i>n</i> = 43) or malignant (<i>n</i> = 37) lesions. The parameters of APTWI and DCE-MRI were compared between the benign and malignant groups. The diagnostic value of 3D-APTWI was evaluated using the area under the receiver operating characteristic curve (ROC-AUC) to establish a diagnostic threshold. Pearson’s correlation was used to analyze the correlation between the magnetization transfer asymmetry (MTR<sub>asym</sub>) and immunohistochemical characteristics.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>The MTR<sub>asym</sub> and time-to-peak of malignancies were significantly lower than those of benign lesions (all <i>p</i> < 0.010). The volume transfer constant, rate constant, and wash-in and wash-out rates of malignancies were all significantly greater than those of benign lesions (all <i>p</i> < 0.010). ROC-AUCs of 3D-APTWI, DCE-MRI, and 3D-APTWI+DCE to differential diagnosis between early-stage BC and benign lesions were 0.816, 0.745, and 0.858, respectively. Only the difference between AUC<sub>APT+DCE</sub> and AUC<sub>DCE</sub> was significant (<i>p</i> < 0.010). When a threshold of MTR<sub>asym</sub> for malignancy for 2.42%, the sensitivity and specificity of 3D-APTWI for BC diagnosis were 86.5% and 67.6%, respectively; MTR<sub>asym</sub> was modestly positively correlated with pathological grade (<i>r</i> = 0.476, <i>p</i> = 0.003) and Ki-67 (<i>r</i> = 0.419, <i>p</i> = 0.020).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions</h3><p>3D-APTWI may be used as a supplementary method for patients with contraindications of DCE-MRI. MTR<sub>asym</sub> can imply the proliferation activities of early-stage BC.</p><h3 data-test=\\\"abstract-sub-heading\\\">Relevance statement</h3><p>3D-APTWI can be an alternative diagnostic method for patients with early-stage BC who are not suitable for contrast injection.</p><h3 data-test=\\\"abstract-sub-heading\\\">Key points</h3><p>• 3D-APTWI reflects the changes in the microenvironment of early-stage breast cancer.</p><p>• Combined 3D-APTWI is superior to DCE-MRI alone for early-stage breast cancer diagnosis.</p><p>• 3D-APTWI improves the diagnostic accuracy of early-stage breast cancer.</p><h3 data-test=\\\"abstract-sub-heading\\\">Graphical Abstract</h3>\\n\",\"PeriodicalId\":36926,\"journal\":{\"name\":\"European Radiology Experimental\",\"volume\":\"268 1\",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-04-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Radiology Experimental\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s41747-024-00439-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Radiology Experimental","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s41747-024-00439-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
3D amide proton transfer-weighted imaging may be useful for diagnosing early-stage breast cancer: a prospective monocentric study
Background
We investigated the value of three-dimensional amide proton transfer-weighted imaging (3D-APTWI) in the diagnosis of early-stage breast cancer (BC) and its correlation with the immunohistochemical characteristics of malignant lesions.
Methods
Seventy-eight women underwent APTWI and dynamic contrast-enhanced (DCE)-MRI. Pathological results were categorized as either benign (n = 43) or malignant (n = 37) lesions. The parameters of APTWI and DCE-MRI were compared between the benign and malignant groups. The diagnostic value of 3D-APTWI was evaluated using the area under the receiver operating characteristic curve (ROC-AUC) to establish a diagnostic threshold. Pearson’s correlation was used to analyze the correlation between the magnetization transfer asymmetry (MTRasym) and immunohistochemical characteristics.
Results
The MTRasym and time-to-peak of malignancies were significantly lower than those of benign lesions (all p < 0.010). The volume transfer constant, rate constant, and wash-in and wash-out rates of malignancies were all significantly greater than those of benign lesions (all p < 0.010). ROC-AUCs of 3D-APTWI, DCE-MRI, and 3D-APTWI+DCE to differential diagnosis between early-stage BC and benign lesions were 0.816, 0.745, and 0.858, respectively. Only the difference between AUCAPT+DCE and AUCDCE was significant (p < 0.010). When a threshold of MTRasym for malignancy for 2.42%, the sensitivity and specificity of 3D-APTWI for BC diagnosis were 86.5% and 67.6%, respectively; MTRasym was modestly positively correlated with pathological grade (r = 0.476, p = 0.003) and Ki-67 (r = 0.419, p = 0.020).
Conclusions
3D-APTWI may be used as a supplementary method for patients with contraindications of DCE-MRI. MTRasym can imply the proliferation activities of early-stage BC.
Relevance statement
3D-APTWI can be an alternative diagnostic method for patients with early-stage BC who are not suitable for contrast injection.
Key points
• 3D-APTWI reflects the changes in the microenvironment of early-stage breast cancer.
• Combined 3D-APTWI is superior to DCE-MRI alone for early-stage breast cancer diagnosis.
• 3D-APTWI improves the diagnostic accuracy of early-stage breast cancer.
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