提高盐酸西格列汀的疗效：通过鼻内途径优化脂质体给药，干预帕金森病

IF 3.6 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Liposome Research Pub Date : 2024-04-09 DOI:10.1080/08982104.2024.2336549

Kartik Bhairu Khot, Sandeep D S, Gopika Gopan, Shridhar Deshpande N, Prajna Shastry, Akshay Bandiwadekar, Jobin Jose

引用次数: 0

摘要

盐酸西格列汀常规剂型的临床用途是减少帕金森病（PD）的进展。然而，盐酸西格列汀进入大脑的途径有限、半衰期较短，以及其...

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Enhancing selegiline hydrochloride efficacy: Box Behnken-optimized liposomal delivery via intranasal route for Parkinson’s disease intervention

The clinical use of selegiline hydrochloride in conventional dosage forms is to reduce the progression of Parkinson’s disease (PD). However, its limited access to the brain, short half-life, and fi...

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来源期刊

Journal of Liposome Research 生物-生化与分子生物学

CiteScore

10.50

自引率

2.30%

发文量

审稿时长

3 months

期刊介绍： The Journal of Liposome Research aims to publish original, high-quality, peer-reviewed research on the topic of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry. Reviews and commentaries or editorials are generally solicited and are editorially reviewed. The Journal also publishes abstracts and conference proceedings including those from the International Liposome Society. The scope of the Journal includes: Formulation and characterisation of systems Formulation engineering of systems Synthetic and physical lipid chemistry Lipid Biology Biomembranes Vaccines Emerging technologies and systems related to liposomes and vesicle type systems Developmental methodologies and new analytical techniques pertaining to the general area Pharmacokinetics, pharmacodynamics and biodistribution of systems Clinical applications. The Journal also publishes Special Issues focusing on particular topics and themes within the general scope of the Journal.