口腔念珠菌病的病理生理微环境

IF 2.2 4区 医学 Q4 IMMUNOLOGY
Apmis Pub Date : 2024-04-04 DOI:10.1111/apm.13412
Mette Rose Jørgensen
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引用次数: 0

摘要

口腔念珠菌病(OC)是口腔黏膜的一种流行性机会性感染,对健康构成了相当大的挑战,尤其是对免疫反应低下、高龄和有局部易感条件的人而言。相当一部分人的口腔中带有念珠菌,但只有少数人会患上口腔念珠菌病。因此,OC 的发病机制可能取决于真菌特性以外的因素,如宿主因素和其他易感因素。粘膜创伤和炎症损害了上皮的完整性,为真菌入侵创造了有利环境。对免疫功能低下状态的分子研究显示,先天性免疫和适应性免疫失调为念珠菌的增殖创造了有利环境。对念珠菌菌种及其毒力因子的详细研究揭示了超越传统白念珠菌关注点的细致入微的理解,其中包括多种念珠菌菌种及其影响粘附、入侵、免疫逃避和生物膜形成的策略。了解 OC 的病理生理微环境对于开发有针对性的治疗干预措施至关重要。本综述旨在揭示影响 OC 发展的各种病理生理微环境,重点关注微生物、宿主和易感因素,并考虑念珠菌对抗真菌治疗的耐药性。这篇综述提供了一个关于 OC 的精细视角,旨在为未来的有效治疗找到潜在的治疗目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Pathophysiological microenvironments in oral candidiasis

Pathophysiological microenvironments in oral candidiasis

Oral candidiasis (OC), a prevalent opportunistic infection of the oral mucosa, presents a considerable health challenge, particularly in individuals with compromised immune responses, advanced age, and local predisposing conditions. A considerable part of the population carries Candida in the oral cavity, but only few develop OC. Therefore, the pathogenesis of OC may depend on factors other than the attributes of the fungus, such as host factors and other predisposing factors. Mucosal trauma and inflammation compromise epithelial integrity, fostering a conducive environment for fungal invasion. Molecular insights into the immunocompromised state reveal dysregulation in innate and adaptive immunity, creating a permissive environment for Candida proliferation. Detailed examination of Candida species (spp.) and their virulence factors uncovers a nuanced understanding beyond traditional C. albicans focus, which embrace diverse Candida spp. and their strategies, influencing adhesion, invasion, immune evasion, and biofilm formation. Understanding the pathophysiological microenvironments in OC is crucial for the development of targeted therapeutic interventions. This review aims to unravel the diverse pathophysiological microenvironments influencing OC development focusing on microbial, host, and predisposing factors, and considers Candida resistance to antifungal therapy. The comprehensive approach offers a refined perspective on OC, seeking briefly to identify potential therapeutic targets for future effective management.

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来源期刊
Apmis
Apmis 医学-病理学
CiteScore
5.20
自引率
0.00%
发文量
91
审稿时长
2 months
期刊介绍: APMIS, formerly Acta Pathologica, Microbiologica et Immunologica Scandinavica, has been published since 1924 by the Scandinavian Societies for Medical Microbiology and Pathology as a non-profit-making scientific journal.
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