基于生物工程弹性蛋白样多肽及其仿生杂交技术的薄膜晶体管装置

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Kyungmin Lee, Hunsang Jung, Heelak Choi, Jong In Won, Hyun Ho Lee
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引用次数: 0

摘要

在这项研究中,生物工程和生物合成的弹性蛋白样多肽(ELP)被用于非易失性记忆电阻开关器件或忆阻器。仿哺乳动物弹性蛋白的 ELP 是通过大肠杆菌基因重组合成的多肽。它们由具有[Val-Pro-Gly-Val-Gly]32序列的重复五肽组成,用于生物电子器件,ELP通过外加电场在高阻态和低阻态之间显示多种电阻状态。此外,镀有 5 纳米金纳米粒子(Au NPs)的 ELP 层也将作为生物材料用于纳米生物混合记忆器件。简单的金属-绝缘体-金属器件结构和在5纳米金纳米粒子上涂有ELP层的横向电极器件可以在水凝胶状态下显示神经形态自适应电流-电压(I-V)行为和电刺激诱导的电位增强和抑制。此外,通过引入神经递质皮质醇的特异性抗体,纳米生物杂交装置还进行了初步的传感试验。因此,将ELP引入神经形态装置被认为是开发生物相容性生物电子装置的基石,这种装置可以集成到人体仿生学中,用于未来的人工神经形态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Memristor device based on bioengineered elastin-like polypeptide and its bionanohybrid

Memristor device based on bioengineered elastin-like polypeptide and its bionanohybrid

In this study, bioengineered and biosynthesized elastin-like polypeptide (ELP) was adopted for a non-volatile memory resistive switching device or a memristor. The ELP mimicked from elastin of mammal was synthetically produced in polypeptide by Escherichia coli gene recombination. They were composed of a repeating pentapeptide sequence having [Val-Pro-Gly-Val-Gly]32 sequence for bioelectronic devices with ELP showing multiple electrical resistance states between a high resistance state and a low resistance state through an applied electrical field. In addition, the ELP-coated 5-nm gold nanoparticles (Au NPs) layer was also to be biomaterials used for nanobiohybrid memristive devices. Simple metal–insulator–metal device structure and lateral electrode device with ELP layer on 5-nm Au NPs could show neuromorphic adaptive current–voltage (IV) behavior and electrical stimulus-induced potentiation and depression in a hydrogel state. In addition, with an introduction of a neurotransmitter cortisol’s specific antibody, a preliminary sensing protocol was also examined with the nanobiohybrid device. Therefore, the introduction of ELP into neuromorphic device is regarded as the cornerstone for the development of biocompatible bioelectronic devices that can be integrated into human bionics for future artificial neuromorphic format.

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来源期刊
Biotechnology and Bioprocess Engineering
Biotechnology and Bioprocess Engineering 工程技术-生物工程与应用微生物
CiteScore
5.00
自引率
12.50%
发文量
79
审稿时长
3 months
期刊介绍: Biotechnology and Bioprocess Engineering is an international bimonthly journal published by the Korean Society for Biotechnology and Bioengineering. BBE is devoted to the advancement in science and technology in the wide area of biotechnology, bioengineering, and (bio)medical engineering. This includes but is not limited to applied molecular and cell biology, engineered biocatalysis and biotransformation, metabolic engineering and systems biology, bioseparation and bioprocess engineering, cell culture technology, environmental and food biotechnology, pharmaceutics and biopharmaceutics, biomaterials engineering, nanobiotechnology, and biosensor and bioelectronics.
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