母亲孕期补充叶酸与儿童超重或肥胖的关系

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-04-04 DOI:10.1002/oby.24012

Chi-Yen Hung, Hsin-Ju Lee, Zhao-Ting Tsai, Shu-Jung Huang, Hsin-Yi Huang, Hui-Ju Tsai, Tsung-Chieh Yao

{"title":"母亲孕期补充叶酸与儿童超重或肥胖的关系","authors":"Chi-Yen Hung, Hsin-Ju Lee, Zhao-Ting Tsai, Shu-Jung Huang, Hsin-Yi Huang, Hui-Ju Tsai, Tsung-Chieh Yao","doi":"10.1002/oby.24012","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study aimed to examine associations of maternal folic acid supplementation (FAS) during pregnancy with childhood overweight or obesity (OWO) or adiposity.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In a population-based cohort of 1479 children, maternal FAS during pregnancy was assessed retrospectively by questionnaires. BMI and body fat percentages were measured at a mean age of 6.4 years. Pertinent factors were accounted for in data analyses.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Maternal FAS during pregnancy was negatively associated with OWO (adjusted odds ratio: 0.70; 95% CI: 0.50 to 0.99). There were inverse associations of maternal FAS during pregnancy with BMI <i>z</i> score (β: −0.22; 95% CI: −0.39 to −0.05), whole body fat percentage (β: −1.28; 95% CI: −2.27 to −0.30), trunk fat percentage (β: −1.41; 95% CI: −2.78 to −0.04), and limb fat percentage (β: −1.31; 95% CI: −2.32 to −0.30). Stratified analyses found inverse associations of FAS during pregnancy with OWO, BMI <i>z</i> score, and body fat percentages predominantly among children without breastfeeding and whose parents had a below-tertiary educational level.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>This study provides novel evidence that maternal FAS during pregnancy was significantly associated with a decreased risk of childhood OWO and adiposity, particularly among children with no breastfeeding and lower parental educational level.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24012","citationCount":"0","resultStr":"{\"title\":\"Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity\",\"authors\":\"Chi-Yen Hung, Hsin-Ju Lee, Zhao-Ting Tsai, Shu-Jung Huang, Hsin-Yi Huang, Hui-Ju Tsai, Tsung-Chieh Yao\",\"doi\":\"10.1002/oby.24012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This study aimed to examine associations of maternal folic acid supplementation (FAS) during pregnancy with childhood overweight or obesity (OWO) or adiposity.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In a population-based cohort of 1479 children, maternal FAS during pregnancy was assessed retrospectively by questionnaires. BMI and body fat percentages were measured at a mean age of 6.4 years. Pertinent factors were accounted for in data analyses.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Maternal FAS during pregnancy was negatively associated with OWO (adjusted odds ratio: 0.70; 95% CI: 0.50 to 0.99). There were inverse associations of maternal FAS during pregnancy with BMI <i>z</i> score (β: −0.22; 95% CI: −0.39 to −0.05), whole body fat percentage (β: −1.28; 95% CI: −2.27 to −0.30), trunk fat percentage (β: −1.41; 95% CI: −2.78 to −0.04), and limb fat percentage (β: −1.31; 95% CI: −2.32 to −0.30). Stratified analyses found inverse associations of FAS during pregnancy with OWO, BMI <i>z</i> score, and body fat percentages predominantly among children without breastfeeding and whose parents had a below-tertiary educational level.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>This study provides novel evidence that maternal FAS during pregnancy was significantly associated with a decreased risk of childhood OWO and adiposity, particularly among children with no breastfeeding and lower parental educational level.</p>\\n </section>\\n </div>\",\"PeriodicalId\":215,\"journal\":{\"name\":\"Obesity\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24012\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/oby.24012\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24012","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

摘要

本研究旨在探讨孕期补充叶酸（FAS）与儿童超重或肥胖（OWO）或脂肪过多之间的关系。方法在一个包含 1479 名儿童的人群队列中，通过问卷对孕期补充叶酸的情况进行了回顾性评估。对平均年龄为 6.4 岁的儿童的体重指数和体脂百分比进行了测量。在数据分析中考虑了相关因素。结果孕妇在怀孕期间出现的 FAS 与 OWO 呈负相关（调整后的几率比：0.70；95% CI：0.50 至 0.99）。孕产妇孕期 FAS 与体重指数 z 值（β：-0.22；95% CI：-0.39 至 -0.05）、全身脂肪百分比（β：-1.28；95% CI：-2.27 至 -0.30）、躯干脂肪百分比（β：-1.41；95% CI：-2.78 至 -0.04）和四肢脂肪百分比（β：-1.31；95% CI：-2.32 至 -0.30）呈负相关。分层分析发现，妊娠期母体脂肪过多症与OWO、BMI z评分和体脂肪百分比呈反向关系，这主要发生在未进行母乳喂养且父母受教育程度低于高等教育的儿童中。结论这项研究提供了新的证据，表明妊娠期母体脂肪过多症与儿童OWO和脂肪过多的风险降低有显著关系，尤其是在未进行母乳喂养且父母受教育程度较低的儿童中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity

查看原文本刊更多论文

Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity

Objective

This study aimed to examine associations of maternal folic acid supplementation (FAS) during pregnancy with childhood overweight or obesity (OWO) or adiposity.

Methods

In a population-based cohort of 1479 children, maternal FAS during pregnancy was assessed retrospectively by questionnaires. BMI and body fat percentages were measured at a mean age of 6.4 years. Pertinent factors were accounted for in data analyses.

Results

Maternal FAS during pregnancy was negatively associated with OWO (adjusted odds ratio: 0.70; 95% CI: 0.50 to 0.99). There were inverse associations of maternal FAS during pregnancy with BMI z score (β: −0.22; 95% CI: −0.39 to −0.05), whole body fat percentage (β: −1.28; 95% CI: −2.27 to −0.30), trunk fat percentage (β: −1.41; 95% CI: −2.78 to −0.04), and limb fat percentage (β: −1.31; 95% CI: −2.32 to −0.30). Stratified analyses found inverse associations of FAS during pregnancy with OWO, BMI z score, and body fat percentages predominantly among children without breastfeeding and whose parents had a below-tertiary educational level.

Conclusions

This study provides novel evidence that maternal FAS during pregnancy was significantly associated with a decreased risk of childhood OWO and adiposity, particularly among children with no breastfeeding and lower parental educational level.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.