估计心肺功能及其动态变化和肥胖与高血压风险的独立和联合关联：一项前瞻性队列研究

IF 2.7 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Human Hypertension Pub Date : 2024-04-10 DOI:10.1038/s41371-024-00910-9

Yang Zhao, Xueru Fu, Yamin Ke, Yuying Wu, Pei Qin, Fulan Hu, Ming Zhang, Dongsheng Hu

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引用次数: 0

摘要

我们的目的是研究在中国农村人口中，估计心肺功能（CRF）及其变化与肥胖与高血压风险之间的独立和联合关系。我们登记了一个前瞻性队列，其中包括 9848 名基线时未患高血压的成年人。通过逻辑回归模型估算了比值比（OR）和 95% 置信区间（95% CI）。剂量-反应关系模型采用限制性三次样条。在 6 年的随访中，共有 2 019 人罹患高血压。估计的 CRF 与高血压发病率之间呈负相关，每增加一个 MET 的风险为 0.87（0.84-0.90）。就估计的 CRF 变化而言，与维持者相比，CRF 下降者和增加者患高血压的风险分别为 1.50（1.27-1.77）和 0.75（0.59-0.97）。联合分析表明，在估计的 CRF 值中，超重/肥胖-4 分位数的人患高血压的风险是体重正常-1 分位数的人的 2.08 倍（Pinteraction < 0.05）。与体重正常者相比，超重/肥胖减少者患高血压的风险最高（OR：2.19，95%CI：1.71-2.81；Pinteraction < 0.05）。腹部肥胖也有类似的结果。在中国农村人口中，估计的 CRF 及其动态变化与高血压发病率呈负相关。

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Independent and joint associations of estimated cardiorespiratory fitness and its dynamic changes and obesity with the risk of hypertension: A prospective cohort

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Independent and joint associations of estimated cardiorespiratory fitness and its dynamic changes and obesity with the risk of hypertension: A prospective cohort

Our aim was to examine the independent and joint associations of estimated cardiorespiratory fitness (CRF) and its changes and obesity with risk of hypertension in a rural Chinese population. A prospective cohort including 9848 adults without hypertension at baseline was enrolled. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated by logistic regression models. Restricted cubic splines were used to model the dose–response relationship. During 6 years follow-up, 2,019 individuals developed hypertension. A negative association between estimated CRF and hypertension incidence was observed, with the risk being 0.87 (0.84–0.90) per MET increment. For estimated CRF change, the risks of hypertension were 1.50 (1.27–1.77) and 0.75 (0.59–0.97) for decreasers and increasers, respectively, compared to maintainers. Joint analyses showed individuals in the overweight/obesity-fourth quartile of estimated CRF had a 2.08 times higher risk of hypertension than those in the normal weight-first quartile (Pinteraction < 0.05). Those overweight/obesity-decreasers had the highest risk (OR: 2.19, 95%CI: 1.71–2.81; Pinteraction < 0.05) compared to the normal-maintainers. Similar results for abdominal obesity were also observed. Estimated CRF and its dynamic changes showed a negative association with hypertension incidence in the rural Chinese population.

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来源期刊

Journal of Human Hypertension 医学-外周血管病

CiteScore

5.20

自引率

3.70%

发文量

126

审稿时长

6-12 weeks

期刊介绍： Journal of Human Hypertension is published monthly and is of interest to health care professionals who deal with hypertension (specialists, internists, primary care physicians) and public health workers. We believe that our patients benefit from robust scientific data that are based on well conducted clinical trials. We also believe that basic sciences are the foundations on which we build our knowledge of clinical conditions and their management. Towards this end, although we are primarily a clinical based journal, we also welcome suitable basic sciences studies that promote our understanding of human hypertension. The journal aims to perform the dual role of increasing knowledge in the field of high blood pressure as well as improving the standard of care of patients. The editors will consider for publication all suitable papers dealing directly or indirectly with clinical aspects of hypertension, including but not limited to epidemiology, pathophysiology, therapeutics and basic sciences involving human subjects or tissues. We also consider papers from all specialties such as ophthalmology, cardiology, nephrology, obstetrics and stroke medicine that deal with the various aspects of hypertension and its complications.