{"title":"硅酸钙基水泥的抗菌、生物相容性和矿化诱导特性","authors":"Taimy Cruz Hondares, Xiaoxiao Hao, Yanfang Zhao, Yuyin Lin, Dobrawa Napierala, Janice G. Jackson, Ping Zhang","doi":"10.1111/ipd.13185","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Different pulp capping materials have different origins and compositions, require different preparations, and may vary in their bioactive properties.</p>\n </section>\n \n <section>\n \n <h3> Aim</h3>\n \n <p>The purpose of this study was to evaluate the antibacterial activity, biocompatibility, and mineralization-inducing potential of calcium silicate-based pulp capping materials.</p>\n </section>\n \n <section>\n \n <h3> Design</h3>\n \n <p>Six contemporary calcium silicate-based cements, ProRoot MTA, MTA Angelus, Biodentine, EndoSequence, NeoMTA 2, and NeoPutty, were evaluated. The antibacterial effects of these materials against <i>Streptococcus mutans</i> UA159 and <i>Enterococcus faecalis</i> ATCC 29212 were determined by the agar diffusion assay and the direct culture test. The biocompatibility and mineralization-inducing potential of these materials in preodontoblastic 17IIA11 cells were evaluated by the MTT assay and by Alizarin Red S staining, respectively.</p>\n </section>\n \n <section>\n \n <h3> Results and Conclusion</h3>\n \n <p>In agar diffusion test, only Biodentine showed distinct antibacterial effects against <i>S. mutans</i>. All the tested materials, however, showed antibacterial effects against <i>S. mutans</i> and <i>E. faecalis</i> in the direct culture test, with Biodentine showing the strongest growth inhibition against both <i>S. mutans</i> and <i>E. faecalis</i>. All the tested materials showed acceptable biocompatibility and mineralization-supporting potential in our experimental conditions. In summary, ProRoot MTA, MTA Angelus, Biodentine, EndoSequence, NeoMTA 2, and NeoPutty demonstrated acceptable in vitro antimicrobial, biocompatible, and mineralization-supporting properties.</p>\n </section>\n </div>","PeriodicalId":14268,"journal":{"name":"International journal of paediatric dentistry","volume":"34 6","pages":"843-852"},"PeriodicalIF":2.3000,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ipd.13185","citationCount":"0","resultStr":"{\"title\":\"Antibacterial, biocompatible, and mineralization-inducing properties of calcium silicate-based cements\",\"authors\":\"Taimy Cruz Hondares, Xiaoxiao Hao, Yanfang Zhao, Yuyin Lin, Dobrawa Napierala, Janice G. Jackson, Ping Zhang\",\"doi\":\"10.1111/ipd.13185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Different pulp capping materials have different origins and compositions, require different preparations, and may vary in their bioactive properties.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>The purpose of this study was to evaluate the antibacterial activity, biocompatibility, and mineralization-inducing potential of calcium silicate-based pulp capping materials.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Design</h3>\\n \\n <p>Six contemporary calcium silicate-based cements, ProRoot MTA, MTA Angelus, Biodentine, EndoSequence, NeoMTA 2, and NeoPutty, were evaluated. The antibacterial effects of these materials against <i>Streptococcus mutans</i> UA159 and <i>Enterococcus faecalis</i> ATCC 29212 were determined by the agar diffusion assay and the direct culture test. The biocompatibility and mineralization-inducing potential of these materials in preodontoblastic 17IIA11 cells were evaluated by the MTT assay and by Alizarin Red S staining, respectively.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results and Conclusion</h3>\\n \\n <p>In agar diffusion test, only Biodentine showed distinct antibacterial effects against <i>S. mutans</i>. All the tested materials, however, showed antibacterial effects against <i>S. mutans</i> and <i>E. faecalis</i> in the direct culture test, with Biodentine showing the strongest growth inhibition against both <i>S. mutans</i> and <i>E. faecalis</i>. All the tested materials showed acceptable biocompatibility and mineralization-supporting potential in our experimental conditions. In summary, ProRoot MTA, MTA Angelus, Biodentine, EndoSequence, NeoMTA 2, and NeoPutty demonstrated acceptable in vitro antimicrobial, biocompatible, and mineralization-supporting properties.</p>\\n </section>\\n </div>\",\"PeriodicalId\":14268,\"journal\":{\"name\":\"International journal of paediatric dentistry\",\"volume\":\"34 6\",\"pages\":\"843-852\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ipd.13185\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of paediatric dentistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ipd.13185\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of paediatric dentistry","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ipd.13185","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Antibacterial, biocompatible, and mineralization-inducing properties of calcium silicate-based cements
Background
Different pulp capping materials have different origins and compositions, require different preparations, and may vary in their bioactive properties.
Aim
The purpose of this study was to evaluate the antibacterial activity, biocompatibility, and mineralization-inducing potential of calcium silicate-based pulp capping materials.
Design
Six contemporary calcium silicate-based cements, ProRoot MTA, MTA Angelus, Biodentine, EndoSequence, NeoMTA 2, and NeoPutty, were evaluated. The antibacterial effects of these materials against Streptococcus mutans UA159 and Enterococcus faecalis ATCC 29212 were determined by the agar diffusion assay and the direct culture test. The biocompatibility and mineralization-inducing potential of these materials in preodontoblastic 17IIA11 cells were evaluated by the MTT assay and by Alizarin Red S staining, respectively.
Results and Conclusion
In agar diffusion test, only Biodentine showed distinct antibacterial effects against S. mutans. All the tested materials, however, showed antibacterial effects against S. mutans and E. faecalis in the direct culture test, with Biodentine showing the strongest growth inhibition against both S. mutans and E. faecalis. All the tested materials showed acceptable biocompatibility and mineralization-supporting potential in our experimental conditions. In summary, ProRoot MTA, MTA Angelus, Biodentine, EndoSequence, NeoMTA 2, and NeoPutty demonstrated acceptable in vitro antimicrobial, biocompatible, and mineralization-supporting properties.
期刊介绍：
The International Journal of Paediatric Dentistry was formed in 1991 by the merger of the Journals of the International Association of Paediatric Dentistry and the British Society of Paediatric Dentistry and is published bi-monthly. It has true international scope and aims to promote the highest standard of education, practice and research in paediatric dentistry world-wide.
International Journal of Paediatric Dentistry publishes papers on all aspects of paediatric dentistry including: growth and development, behaviour management, diagnosis, prevention, restorative treatment and issue relating to medically compromised children or those with disabilities. This peer-reviewed journal features scientific articles, reviews, case reports, clinical techniques, short communications and abstracts of current paediatric dental research. Analytical studies with a scientific novelty value are preferred to descriptive studies. Case reports illustrating unusual conditions and clinically relevant observations are acceptable but must be of sufficiently high quality to be considered for publication; particularly the illustrative material must be of the highest quality.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
