研究超声波辐照的功率和持续时间对噻唑合成的影响

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Current organic synthesis Pub Date : 2024-04-13 DOI:10.2174/0115701794287558240220115823

Eghlima Ehsani, Afshin Sarvary, Setareh Habibzadeh

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引用次数: 0

摘要

引言研究了超声波辐照的功率和持续时间对通过 Hantzsch 反应合成噻唑类化合物的影响。研究方法在超声波辐照下，苯酰基溴与硫代酰胺反应生成目标噻唑，产率良好。结果结果表明，高功率和长辐照时间会导致反应物的分解。对于该反应，720 瓦的辐照功率和 4 分钟的总辐照时间（每秒 50%的时间执行脉冲功能）被认为是通过 Hantzsch 反应合成噻唑的最合适的辐照特性。结论本方法具有条件温和、时间短、产率高、反应产物分离简单以及无需使用碱进行中和等优点。

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Investigation of the Effect of Power and Duration of Ultrasonic Irradiation on the Synthesis of Thiazoles

Introduction: The effect of power and duration of ultrasonic irradiation on the syn-thesis of thiazoles via the Hantzsch reaction was investigated. Methods: The reaction of phenacyl bromides with thioamides under ultrasonic irradiation af-forded the target thiazoles in good yields. Results: The results showed that high power and long irradiation time cause the decomposition of the reaction materials, and for this reaction, the irradiation power of 720 watts and a total duration of 4 minutes, wherein a pulsing function was performed in 50% of each second, were considered the most suitable irradiation properties for the synthesis of thiazoles through the Hantzsch reaction. Conclusion: The use of mild conditions, short time frame, high yields, simple separation of the reaction product, and no use of the base for neutralization are the advantages of the present method.

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来源期刊

Current organic synthesis 化学-有机化学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Organic Synthesis publishes in-depth reviews, original research articles and letter/short communications on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.