{"title":"高度散光患者接受飞秒激光辅助 LASIK 手术后不同区域角膜上皮厚度的变化","authors":"Anqi Li, MD, Zhichao Liu, MD, Meng Lin, MD, Qianwen Gong, MD, PhD, Linzhi Wei, MD, Fan Lu, MD, OD, Liang Hu, MD, OD","doi":"10.3928/1081597x-20240311-04","DOIUrl":null,"url":null,"abstract":"<section><h3>Purpose:</h3><p>To explore changes in corneal epithelial thickness (CET) after femtosecond laser–assisted laser in situ keratomileusis in patients with high astigmatism.</p></section><section><h3>Methods:</h3><p>CET was measured at every intersection of the concentric circles and specific axes using AngioVue optical coherence tomography (Angio-OCT) preoperatively and 1 month postoperatively. The average thickness of corneal central, paracentral, and peripheral regions was the mean of the points within the central 2, 2 to 5, and 5 to 7 mm areas, respectively. Correlation analysis was performed to investigate the association between CET along different axes and other preoperative and postoperative parameters.</p></section><section><h3>Results:</h3><p>Forty-two eyes of 28 patients were included. CET along the astigmatic (K1) and perpendicular (K2) axes in the central and paracentral areas increased (<i>P</i> < .001), whereas that along the K2 axis decreased in the peripheral area 1 month postoperatively (<i>P</i> = .001). The amount of CET change in the peripheral area between the K1 and K2 axes was significantly different (<i>P</i> < .001). In the central area, the change in CET along the K2 axis was positively correlated with ablation depth (<i>r</i> = 0.315, <i>P</i> = .042) and negatively with refractive power after surgery (<i>r</i> = −0.347, <i>P</i> = .024). In the peripheral area, the changes in CET along both K1 and K2 axes were negatively correlated with ablation depth (<i>r</i> = −0.431, <i>P</i> = .004; <i>r</i> = −0.387, <i>P</i> = .011, respectively).</p></section><section><h3>Conclusions:</h3><p>Epithelial modeling differed between the different astigmatism axes after refractive surgery. The compensatory response of the corneal epithelium is more pronounced along the steeper axis.</p><p><strong>[<i>J Refract Surg</i>. 2024;40(4):e239–e244.]</strong></p></section>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"116 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Changes in Corneal Epithelial Thickness in Different Areas After Femtosecond Laser–Assisted LASIK in Patients With High Astigmatism\",\"authors\":\"Anqi Li, MD, Zhichao Liu, MD, Meng Lin, MD, Qianwen Gong, MD, PhD, Linzhi Wei, MD, Fan Lu, MD, OD, Liang Hu, MD, OD\",\"doi\":\"10.3928/1081597x-20240311-04\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<section><h3>Purpose:</h3><p>To explore changes in corneal epithelial thickness (CET) after femtosecond laser–assisted laser in situ keratomileusis in patients with high astigmatism.</p></section><section><h3>Methods:</h3><p>CET was measured at every intersection of the concentric circles and specific axes using AngioVue optical coherence tomography (Angio-OCT) preoperatively and 1 month postoperatively. The average thickness of corneal central, paracentral, and peripheral regions was the mean of the points within the central 2, 2 to 5, and 5 to 7 mm areas, respectively. Correlation analysis was performed to investigate the association between CET along different axes and other preoperative and postoperative parameters.</p></section><section><h3>Results:</h3><p>Forty-two eyes of 28 patients were included. CET along the astigmatic (K1) and perpendicular (K2) axes in the central and paracentral areas increased (<i>P</i> < .001), whereas that along the K2 axis decreased in the peripheral area 1 month postoperatively (<i>P</i> = .001). The amount of CET change in the peripheral area between the K1 and K2 axes was significantly different (<i>P</i> < .001). In the central area, the change in CET along the K2 axis was positively correlated with ablation depth (<i>r</i> = 0.315, <i>P</i> = .042) and negatively with refractive power after surgery (<i>r</i> = −0.347, <i>P</i> = .024). In the peripheral area, the changes in CET along both K1 and K2 axes were negatively correlated with ablation depth (<i>r</i> = −0.431, <i>P</i> = .004; <i>r</i> = −0.387, <i>P</i> = .011, respectively).</p></section><section><h3>Conclusions:</h3><p>Epithelial modeling differed between the different astigmatism axes after refractive surgery. The compensatory response of the corneal epithelium is more pronounced along the steeper axis.</p><p><strong>[<i>J Refract Surg</i>. 2024;40(4):e239–e244.]</strong></p></section>\",\"PeriodicalId\":16951,\"journal\":{\"name\":\"Journal of refractive surgery\",\"volume\":\"116 1\",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of refractive surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3928/1081597x-20240311-04\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of refractive surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/1081597x-20240311-04","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Changes in Corneal Epithelial Thickness in Different Areas After Femtosecond Laser–Assisted LASIK in Patients With High Astigmatism
Purpose:
To explore changes in corneal epithelial thickness (CET) after femtosecond laser–assisted laser in situ keratomileusis in patients with high astigmatism.
Methods:
CET was measured at every intersection of the concentric circles and specific axes using AngioVue optical coherence tomography (Angio-OCT) preoperatively and 1 month postoperatively. The average thickness of corneal central, paracentral, and peripheral regions was the mean of the points within the central 2, 2 to 5, and 5 to 7 mm areas, respectively. Correlation analysis was performed to investigate the association between CET along different axes and other preoperative and postoperative parameters.
Results:
Forty-two eyes of 28 patients were included. CET along the astigmatic (K1) and perpendicular (K2) axes in the central and paracentral areas increased (P < .001), whereas that along the K2 axis decreased in the peripheral area 1 month postoperatively (P = .001). The amount of CET change in the peripheral area between the K1 and K2 axes was significantly different (P < .001). In the central area, the change in CET along the K2 axis was positively correlated with ablation depth (r = 0.315, P = .042) and negatively with refractive power after surgery (r = −0.347, P = .024). In the peripheral area, the changes in CET along both K1 and K2 axes were negatively correlated with ablation depth (r = −0.431, P = .004; r = −0.387, P = .011, respectively).
Conclusions:
Epithelial modeling differed between the different astigmatism axes after refractive surgery. The compensatory response of the corneal epithelium is more pronounced along the steeper axis.
期刊介绍：
The Journal of Refractive Surgery, the official journal of the International Society of Refractive Surgery, a partner of the American Academy of Ophthalmology, has been a monthly peer-reviewed forum for original research, review, and evaluation of refractive and lens-based surgical procedures for more than 30 years. Practical, clinically valuable articles provide readers with the most up-to-date information regarding advances in the field of refractive surgery. Begin to explore the Journal and all of its great benefits such as:
• Columns including “Translational Science,” “Surgical Techniques,” and “Biomechanics”
• Supplemental videos and materials available for many articles
• Access to current articles, as well as several years of archived content
• Articles posted online just 2 months after acceptance.
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