体质指数(BMI)升高对 COVID-19 后遗症患者认知功能和炎症的影响:二次分析

IF 3.8 4区 医学 Q1 Medicine
Gia Han Le, Angela T.H. Kwan, Ziji Guo, Sabrina Wong, Sebastian Badulescu, Hartej Gill, Kayla M. Teopiz, Shakila Meshkat, Felicia Ceban, Lee Phan, Mehala Subramaniapillai, Joshua D. Di Vincenzo, Joshua D. Rosenblat, Rodrigo B. Mansur, Giacomo d’Andrea, Roger Ho, Taeho Greg Rhee, Roger S. McIntyre
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引用次数: 0

摘要

摘要 背景:从SARS-CoV-2感染的急性期康复后的人可能有患COVID-19后病症(PCC)的风险,该病症的特点是在多个器官系统中出现一系列持续性、非特异性和功能受损的症状。肥胖被认为是 PCC 的一个风险因素,它是由慢性全身性炎症介导的。另有报道称,上述因素也是 PCC 认知功能障碍的诱因。研究方法这是对一项随机、双盲、安慰剂对照临床试验的事后分析,该试验评估了伏替西汀治疗 PCC 患者认知障碍的效果,患者接受了为期八周的伏替西汀或安慰剂治疗。该分析包括基线数据,通过数字符号替换测试(DSST)和路径制作测试(TMT)-A/B,以及血清 c 反应蛋白(CRP)和红细胞沉降率(ESR),研究 BMI 对认知功能的影响。研究结果对 70 名参与者的完整数据进行了统计分析,并根据年龄和性别进行了调整。体重指数与 DSST(β=-0.003,p=0.047)、TMT-A(β=-0.006,p=0.025)和 TMT-B (β=-0.006,p=0.002)的成绩呈负相关。体重指数与血清 CRP(非标准化 β=0.193,标准化 β=0.612,p<0.001)和 ESR(β=0.039,p<0.001)水平呈正相关。结论我们观察到,在 PCC 患者中,体重指数与认知功能之间存在明显的负相关,而体重指数与炎症之间存在明显的正相关,这表明体重指数、PCC 和认知功能之间存在双向的相互作用;体重指数升高的人患 PCC 的风险可能更大,并且/或者在慢性系统炎症的介导下出现更大的认知缺陷。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Elevated Body Mass Index (BMI) on Cognitive Functioning and Inflammation in Persons with Post-COVID-19 Condition: A Secondary Analysis
ABSTRACT Background: Individuals who have recovered from the acute stage of SARS-CoV-2 infection may be at risk of developing post-COVID-19 condition (PCC), characterized by a spectrum of persisting, non-specific, and functionally impairing symptoms across multiple organ systems. Obesity has been implicated as a risk factor for PCC, mediated by chronic systemic inflammation. The foregoing has also been separately reported to mediate cognitive dysfunction in PCC. Methods: This is a post-hoc analysis of a randomized, double-blinded, placebo-controlled clinical trial evaluating vortioxetine treatment for cognitive impairments in persons with PCC who received vortioxetine or placebo for eight weeks. This analysis comprises baseline data, examining the impacts of BMI on cognitive functioning measured by the Digit Symbol Substitution Test (DSST) and Trails Making Tests (TMT)-A/B, as well as inflammation, via serum c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Results: Complete data from 70 participants were statistically analyzed and adjusted for age and sex. BMI is negatively correlated with performance on the DSST (β=-0.003, p=0.047), TMT-A (β=-0.006, p=0.025), and TMT-B (β=-0.006, p=0.002). BMI is positively correlated with serum CRP (unstandardized β=0.193, standardized β=0.612, p<0.001) and ESR (β=0.039, p<0.001) levels. Conclusion: We observed a significant negative correlation between BMI and cognitive functioning, and a significant positive correlation between BMI and inflammation in persons with PCC, suggesting a bidirectional interplay between BMI, PCC, and cognitive function; individuals with an elevated BMI may be at a greater risk of developing PCC and/or presenting with greater cognitive deficits mediated by chronic systemic inflammation.
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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