残余胆固醇与主要不良心血管事件风险：队列研究的系统回顾和剂量反应荟萃分析。

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Coronary artery disease Pub Date : 2024-04-08 DOI:10.1097/mca.0000000000001361

Xiaoran Bian, Yonghao Zhang, Min Shao, Jiachen Li, Jiaju Ge, Zhuofan Li, Hao Peng, Mingzhi Zhang

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引用次数: 0

摘要

新的证据表明，残余胆固醇在造成与重大不良心血管事件（MACE）相关的残余风险方面起着重要作用。本研究旨在评估残余胆固醇与 MACE 风险之间的剂量-反应关系。研究人员查阅了 PubMed、Embase 和 Cochrane 数据库，以确定截至 2023 年 8 月 1 日用英语发表的队列研究。共筛选出 28 篇文章。采用固定或随机效应模型计算了汇总的危险比（HR）及其95%置信区间（CI），以评估残余胆固醇与MACE风险之间的关系。使用线性模型和限制性三次样条回归模型分析了残余胆固醇水平与 MACE 风险之间的剂量-反应关系。对于计算出的残余胆固醇水平，每增加 1-SD 的 MACE 合并 HR（95% CI）为 1.13（1.08, 1.17）；与最低四分位数（Q1）相比，残余胆固醇水平的第二四分位数（Q2）、第三四分位数（Q3）和最高四分位数（Q4）的HR（95% CI）分别为1.14（1.03，1.25）、1.43（1.23，1.68）和1.68（1.44，1.97）。就测量的残余胆固醇水平而言，每增加 1-SD 的 MACE 合并 HR（95% CI）为 1.67（1.39, 2.01）。剂量反应荟萃分析显示，残余胆固醇水平与 MACE 风险之间存在剂量反应关系，既有线性趋势（P <0.0001），也有非线性趋势（P <0.0001）。MACE 风险与残余胆固醇水平升高有关，残余胆固醇水平与 MACE 风险之间的剂量反应关系既呈线性趋势，也呈非线性趋势。

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Remnant cholesterol and risk of major adverse cardiovascular events: a systematic review and dose-response meta-analysis of cohort studies.

Emerging evidence indicates a significant role of remnant cholesterol in contributing to the residual risk associated with major adverse cardiovascular events (MACE). This study aims to evaluate the dose-response relationship between remnant cholesterol and the risk of MACE. PubMed, Embase and Cochrane databases were reviewed to identify cohort studies published in English up to 1 August 2023. Twenty-eight articles were selected. Pooled hazard ratios (HR) and their 95% confidence intervals (CIs) were calculated using fixed or random-effects models to evaluate the association between remnant cholesterol and the risk of MACE. The dose-response relationship between remnant cholesterol levels and the risk of MACE was analyzed using the linear model and restricted cubic spline regression models. For calculated remnant cholesterol levels, the pooled HR (95% CI) of MACE for per 1-SD increase was 1.13 (1.08, 1.17); HR (95% CI) for the second quartile (Q2), the third quartile (Q3) and the highest quartile (Q4) of remnant cholesterol levels were 1.14 (1.03, 1.25), 1.43 (1.23, 1.68) and 1.68 (1.44, 1.97), respectively, compared with the lowest quartile (Q1). For measured remnant cholesterol levels, the pooled HR (95% CI) of MACE per 1-SD increase was 1.67 (1.39, 2.01). The dose-response meta-analysis showed a dose-response relationship between remnant cholesterol levels and the risk of MACE, both on a linear trend (P < 0.0001) and a nonlinear trend (P < 0.0001). The risk of MACE is associated with increased levels of remnant cholesterol, and the dose-response relationship between remnant cholesterol levels and the risk of MACE showed both linear and nonlinear trends.

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.