用食人鱼溶液和表没食子儿茶素-3-棓酸盐涂层处理的高性能聚醚醚酮聚合物的评估

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Mohammed A. Alsmael, Aseel Mohammed Al-Khafaji
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引用次数: 0

摘要

背景。牙科植入手术已成为一种标准手术,成功率很高,这有赖于植入体表面与周围骨组织之间的骨结合。聚醚醚酮(PEEK)是钛等传统牙科植入材料的理想替代品,但由于其疏水性质和表面粗糙度较低,其骨结合能力受到限制。研究目的本研究的目的是用食人鱼溶液处理 PEEK 表面,然后用电喷雾技术在其表面涂覆表没食子儿茶素-3-棓酸盐(EGCG),以增加其表面粗糙度和亲水性。材料与方法。研究包括四组,旨在考察食人鱼处理和 EGCG 涂层的效果:未处理的 PEEK 盘对照组(C)、用食人鱼溶液处理的 PEEK 样品组(P)、涂有 EGCG 的 PEEK 样品组(E)以及用食人鱼溶液处理并涂有 EGCG 的 PEEK 样品组(PE)。通过统计分析评估了表面粗糙度、润湿性和微硬度。结果显示食人鱼处理增加了表面粗糙度,而 EGCG 涂层则缓和了表面粗糙度,因此 PE 组的表面粗糙度处于中等水平。EGCG 明显改善了润湿性,这体现在接触角的减小上。与未涂覆组相比,涂覆 EGCG 组的显微硬度提高了约 20%。统计分析证实,各组之间在所有测试中均存在明显差异。结论这项研究证明了 EGCG 涂层在提高牙科植入物 PEEK 表面特性方面的潜力。结合食人鱼和 EGCG 的改性方法有望改善骨结合,但还需要进一步的体内研究。表面改性技术是优化生物材料性能的关键,是弥合牙科种植中实验室研究结果与临床应用之间差距的桥梁。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of High-Performance Polyether Ether Ketone Polymer Treated with Piranha Solution and Epigallocatechin-3-Gallate Coating
Background. Dental implantation has become a standard procedure with high success rates, relying on achieving osseointegration between the implant surface and surrounding bone tissue. Polyether ether ketone (PEEK) is a promising alternative to traditional dental implant materials like titanium, but its osseointegration capabilities are limited due to its hydrophobic nature and reduced surface roughness. Objective. The aim of the study is to increase the surface roughness and hydrophilicity of PEEK by treating the surface with piranha solution and then coating the surface with epigallocatechin-3-gallate (EGCG) by electrospraying technique. Materials and Methods. The study includes four groups intended to investigate the effect of piranha treatment and EGCG coating: a control group of PEEK discs with no treatment (C), PEEK samples treated with piranha solution (P), a group of PEEK samples coated with EGCG (E), and a group of PEEK samples treated with piranha solution and coated with EGCG (PE). Surface roughness, wettability, and microhardness were assessed through statistical analysis. Results. Piranha treatment increased surface roughness, while EGCG coating moderated it, resulting in an intermediate roughness in the PE group. EGCG significantly improved wettability, as indicated by the reduced contact angle. Microhardness increased by about 20% in EGCG-coated groups compared to noncoated groups. Statistical analysis confirmed significant differences between groups in all tests. Conclusion. This study demonstrates the potential of EGCG coating to enhance the surface properties of PEEK as dental implants. The combined piranha and EGCG modification approach shows promise for improved osseointegration, although further vivo research is necessary. Surface modification techniques hold the key to optimizing biomaterial performance, bridging the gap between laboratory findings and clinical implementation in dental implantology.
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来源期刊
BioMed Research International
BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.70
自引率
0.00%
发文量
1942
审稿时长
19 weeks
期刊介绍: BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
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