研究人类巨噬细胞的方法

IF 13.1 1区 医学 Q1 IMMUNOLOGY
Yuzhou Bao, Guanlin Wang, Hanjie Li
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引用次数: 0

摘要

巨噬细胞是参与器官生成、维持体内平衡和应对疾病的重要组织成分。小鼠模型大大提高了我们对巨噬细胞的认识。考虑到小鼠和人类在解剖学和生理学上的巨大差异,进一步研究人类巨噬细胞的特征和发育至关重要。尽管人类巨噬细胞研究面临挑战,但最近的研究正在揭示人类巨噬细胞的本体和功能。在本文中,我们提出了一些前沿方法的组合,以研究人类组织驻留巨噬细胞的多样性、发育、生态位和功能。这些方法有助于我们更有效地探索人类巨噬细胞,从而为巨噬细胞相关疾病提供新的治疗途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Approaches for studying human macrophages
Macrophages are vital tissue components involved in organogenesis, maintaining homeostasis, and responses to disease. Mouse models have significantly improved our understanding of macrophages. Further investigations into the characteristics and development of human macrophages are crucial, considering the substantial anatomical and physiological distinctions between mice and humans. Despite challenges in human macrophage research, recent studies are shedding light on the ontogeny and function of human macrophages. In this opinion, we propose combinations of cutting-edge approaches to examine the diversity, development, niche, and function of human tissue-resident macrophages. These methodologies can facilitate our exploration of human macrophages more efficiently, ideally providing new therapeutic avenues for macrophage-relevant disorders.
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来源期刊
Trends in Immunology
Trends in Immunology 医学-免疫学
CiteScore
25.10
自引率
0.60%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.
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