俄罗斯鄂木斯克州不同结核分枝杆菌基因型的抗药性

IF 1.3 4区生物学 Q4 MICROBIOLOGY

Microbiology Pub Date : 2024-04-02 DOI:10.1134/s002626172360444x

A. A. Vyazovaya, I. V. Kostyukova, A. A. Gerasimova, D. R. Terentieva, O. A. Pasechnik, I. V. Mokrousov

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引用次数: 0

摘要

摘要对从 2019-2020 年鄂木斯克州新诊断的肺结核患者中分离出的 397 株结核分枝杆菌进行了基因分型。北京基因型菌株（70.8%）的流行率，尤其是两个现代亚系群的流行率：中亚/俄罗斯（46.1%）和 B0/W148（19.1%）。北京基因型的古老亚系菌株以 1071-32 和 14717-15 群为代表，共占 4.8%。与其他基因型相比，B0/W148 群和北京古老亚系的菌株更多地具有多药耐药性（MDR）：分别为 93.4%和 94.7%（P <0.0001）。在其他基因家族（LAM、Ural、T、Haarlem）成员中，对药物敏感的菌株占多数（75.0%）。鉴于北京 MDR 菌株可能会在更大范围内传播，因此需要对其进行分子流行病学监测。

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Drug Resistance of Different Mycobacterium tuberculosis Genotypes in the Omsk Oblast of Russia

Abstract

A total of 397 strains of Mycobacterium tuberculosis isolated from newly diagnosed patients with pulmonary tuberculosis in the Omsk oblast in 2019–2020 were genotyped. The prevalence of the Beijing genotype strains (70.8%), in particular, of two modern sublineage clusters: Central Asian/Russian (46.1%) and B0/W148 (19.1%), was established. Strains of the ancient sublineage of the Beijing genotype were represented by clusters 1071-32 and 14717-15, totaling 4.8%. Compared with other genotypes, the strains of B0/W148-cluster and the ancient Beijing sublineage were more often characterized by multidrug resistance (MDR): 93.4 and 94.7%, respectively (P < 0.0001). Among members of other genetic families (LAM, Ural, T, Haarlem), drug-sensitive strains predominated (75.0%). The circulation of MDR Beijing strains requires molecular epidemiological surveillance in view of their possible wider spread.

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来源期刊

Microbiology 生物-微生物学

CiteScore

2.40

自引率

13.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Microbiology is an is an international peer reviewed journal that covers a wide range of problems in the areas of fundamental and applied microbiology. The journal publishes experimental and theoretical papers, reviews on modern trends in different fields of microbiological science, and short communications with descriptions of unusual observations. The journal welcomes manuscripts from all countries in the English or Russian language.