A. V. Belikov, Y. V. Fyodorova, A. D. Kozlova, S. N. Smirnov
{"title":"波长为 450 纳米的激光照射下用于治疗甲癣的现代含氯药物的激光传输和光谱研究","authors":"A. V. Belikov, Y. V. Fyodorova, A. D. Kozlova, S. N. Smirnov","doi":"10.1134/s0030400x2310003x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The possibility of active laser delivery of a modern chlorine-containing photosensitizing drug Chloderm (Chloderm, Russia) under the nail plate by laser radiation with a wavelength of 450 nm for the purpose of photodynamic therapy of onychomycosis is studied. In an in vitro experiment, sequential laser microporation of the nail plate and active delivery of the drug under the nail plate by this laser radiation with an intensity of up to 200 W/cm<sup>2</sup> were investigated. The results of studying the absorption spectra of an aqueous solution of Chloderm in the range of 400–900 nm before and after exposure to 450 nm laser radiation are presented. It is demonstrated that sequential laser microporation and active laser drug delivery under the nail plate is possible at laser radiation intensity greater than 178 W/cm<sup>2</sup>. It is shown that the maximum rate and efficiency of nail plate ablation by 450 nm laser radiation is achieved at an intensity of 200 W/cm<sup>2</sup> and is 2750 ± 30 μm/s and 1.47 ± 0.05 μm/mJ, respectively. The delivery rate of Chloderm under the nail plate is 1.15 ± 0.1 mg/s. It is shown that exposure to 450 nm laser radiation at the intensity of 200 W/cm<sup>2</sup> for a time sufficient to deliver the drug under the nail plate does not change the extinction coefficient of the drug at the laser wavelength and slightly changes the conformational state of Chloderm.</p>","PeriodicalId":723,"journal":{"name":"Optics and Spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Laser Delivery and Spectral Study of a Modern Chlorine-Containing Drug for the Treatment of Onychomycosis at Laser Radiation with a Wavelength of 450 nm\",\"authors\":\"A. V. Belikov, Y. V. Fyodorova, A. D. Kozlova, S. N. Smirnov\",\"doi\":\"10.1134/s0030400x2310003x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>The possibility of active laser delivery of a modern chlorine-containing photosensitizing drug Chloderm (Chloderm, Russia) under the nail plate by laser radiation with a wavelength of 450 nm for the purpose of photodynamic therapy of onychomycosis is studied. In an in vitro experiment, sequential laser microporation of the nail plate and active delivery of the drug under the nail plate by this laser radiation with an intensity of up to 200 W/cm<sup>2</sup> were investigated. The results of studying the absorption spectra of an aqueous solution of Chloderm in the range of 400–900 nm before and after exposure to 450 nm laser radiation are presented. It is demonstrated that sequential laser microporation and active laser drug delivery under the nail plate is possible at laser radiation intensity greater than 178 W/cm<sup>2</sup>. It is shown that the maximum rate and efficiency of nail plate ablation by 450 nm laser radiation is achieved at an intensity of 200 W/cm<sup>2</sup> and is 2750 ± 30 μm/s and 1.47 ± 0.05 μm/mJ, respectively. The delivery rate of Chloderm under the nail plate is 1.15 ± 0.1 mg/s. It is shown that exposure to 450 nm laser radiation at the intensity of 200 W/cm<sup>2</sup> for a time sufficient to deliver the drug under the nail plate does not change the extinction coefficient of the drug at the laser wavelength and slightly changes the conformational state of Chloderm.</p>\",\"PeriodicalId\":723,\"journal\":{\"name\":\"Optics and Spectroscopy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Optics and Spectroscopy\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1134/s0030400x2310003x\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"OPTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Optics and Spectroscopy","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1134/s0030400x2310003x","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OPTICS","Score":null,"Total":0}
Laser Delivery and Spectral Study of a Modern Chlorine-Containing Drug for the Treatment of Onychomycosis at Laser Radiation with a Wavelength of 450 nm
Abstract
The possibility of active laser delivery of a modern chlorine-containing photosensitizing drug Chloderm (Chloderm, Russia) under the nail plate by laser radiation with a wavelength of 450 nm for the purpose of photodynamic therapy of onychomycosis is studied. In an in vitro experiment, sequential laser microporation of the nail plate and active delivery of the drug under the nail plate by this laser radiation with an intensity of up to 200 W/cm2 were investigated. The results of studying the absorption spectra of an aqueous solution of Chloderm in the range of 400–900 nm before and after exposure to 450 nm laser radiation are presented. It is demonstrated that sequential laser microporation and active laser drug delivery under the nail plate is possible at laser radiation intensity greater than 178 W/cm2. It is shown that the maximum rate and efficiency of nail plate ablation by 450 nm laser radiation is achieved at an intensity of 200 W/cm2 and is 2750 ± 30 μm/s and 1.47 ± 0.05 μm/mJ, respectively. The delivery rate of Chloderm under the nail plate is 1.15 ± 0.1 mg/s. It is shown that exposure to 450 nm laser radiation at the intensity of 200 W/cm2 for a time sufficient to deliver the drug under the nail plate does not change the extinction coefficient of the drug at the laser wavelength and slightly changes the conformational state of Chloderm.
期刊介绍:
Optics and Spectroscopy (Optika i spektroskopiya), founded in 1956, presents original and review papers in various fields of modern optics and spectroscopy in the entire wavelength range from radio waves to X-rays. Topics covered include problems of theoretical and experimental spectroscopy of atoms, molecules, and condensed state, lasers and the interaction of laser radiation with matter, physical and geometrical optics, holography, and physical principles of optical instrument making.