原发性脊柱硬膜外肿瘤的患者报告结果:系统性综述

IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY
Ahmad M. S. Ali, Mohammad A. Mustafa, Omar M. E. Ali, Conor S. Gillespie, George M. Richardson, Simon Clark, Martin J. Wilby, Christopher P. Millward, Nisaharan Srikandarajah
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引用次数: 0

摘要

研究设计系统性综述。研究目的原发性脊柱硬膜内肿瘤(PSITs)是一种罕见病,会严重影响患者的生活质量。本研究旨在回顾 PSITs 患者报告的结果 (PRO)。方法对 Pubmed 和 Embase 进行了系统性检索,以确定测量 PSITs 成人患者 PRO 的研究。PRO结果被分为与整体健康、身体健康、社交健康或心理健康相关的几类。结果在对 2382 条记录进行审查后,有 11 项研究符合纳入条件(737 名患者)。所有研究都对接受过手术治疗的患者进行了评估。最常见的病理是许旺瘤(n = 190)。7 项研究测量了手术前后的 PROs,其余研究仅评估了手术后的 PROs。有 8 项研究在治疗后 12 个月内获得了患者的 PROs。纳入研究中使用了 21 种 PRO 测量工具,其中最常用的是 Euro-Qol-5D(8 项)和疼痛视觉/数字模拟量表(5 项)。虽然 PSITs 患者的总体 QoL 低于健康对照组,但在髓外肿瘤(EMT)患者手术后,其总体身体、社交和心理健康均有所改善。在髓内肿瘤(IMT)的各项研究中,类似的改善并不明显。髓内肿瘤患者的总体生活质量和症状负担高于脑肿瘤患者。没有研究对化疗或放疗的效果进行评估。结论PSITs患者在手术前后的PRO都会受到影响,IMT患者尤其如此。PSITs患者的PRO报告因报告的异质性和测量工具的多样性而受到阻碍。这就需要建立一套标准的PRO,并使用登记册。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Patient-reported outcomes in Primary Spinal Intradural Tumours: a systematic review

Patient-reported outcomes in Primary Spinal Intradural Tumours: a systematic review

Patient-reported outcomes in Primary Spinal Intradural Tumours: a systematic review
Systematic review. Primary Spinal Intradural Tumours (PSITs) are rare pathologies that can significantly impact quality of life. This study aimed to review patient reported outcomes (PROs) in PSITs. A systematic search of Pubmed and Embase was performed to identify studies measuring PROs in adults with PSITs. PRO results were categorised as relating to Global, Physical, Social, or Mental health. Outcomes were summarised descriptively. Following review of 2382 records, 11 studies were eligible for inclusion (737 patients). All studies assessed surgically treated patients. Schwannoma was the commonest pathology (n = 190). 7 studies measured PROs before and after surgery, the remainder assessed only post-operatively. For eight studies, PROs were obtained within 12 months of treatment. 21 PRO measurement tools were used across included studies, of which Euro-Qol-5D (n = 8) and the pain visual/numerical analogue scale (n = 5) were utilised most frequently. Although overall QoL is lower than healthy controls in PSITs, improvements following surgery were found in Extramedullary tumours (EMT) in overall physical, social, and mental health. Similar improvements were not significant across studies of Intramedullary tumours (IMT). Overall QoL and symptom burden was higher in IMT patients than in brain tumour patients. No studies evaluated the effect of chemotherapy or radiotherapy. Patients with PSITs suffer impaired PROs before and after surgery. This is particularly true for IMTs. PRO reporting in PSITs is hindered by a heterogeneity of reporting and varied measurement tools. This calls for the establishment of a standard set of PROs as well as the use of registries.
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来源期刊
Spinal cord
Spinal cord 医学-临床神经学
CiteScore
4.50
自引率
9.10%
发文量
142
审稿时长
2 months
期刊介绍: Spinal Cord is a specialised, international journal that has been publishing spinal cord related manuscripts since 1963. It appears monthly, online and in print, and accepts contributions on spinal cord anatomy, physiology, management of injury and disease, and the quality of life and life circumstances of people with a spinal cord injury. Spinal Cord is multi-disciplinary and publishes contributions across the entire spectrum of research ranging from basic science to applied clinical research. It focuses on high quality original research, systematic reviews and narrative reviews. Spinal Cord''s sister journal Spinal Cord Series and Cases: Clinical Management in Spinal Cord Disorders publishes high quality case reports, small case series, pilot and retrospective studies perspectives, Pulse survey articles, Point-couterpoint articles, correspondences and book reviews. It specialises in material that addresses all aspects of life for persons with spinal cord injuries or disorders. For more information, please see the aims and scope of Spinal Cord Series and Cases.
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