IL-2 介导的肝毒性：基于 irAOP 概念的知识差距识别

IF 2.4 4区医学 Q3 TOXICOLOGY

Journal of Immunotoxicology Pub Date : 2024-04-05 DOI:10.1080/1547691x.2024.2332177

Luise A. Roser, Christina Sakellariou, Malin Lindstedt, Vanessa Neuhaus, Susann Dehmel, Charline Sommer, Martin Raasch, Thierry Flandre, Sigrid Roesener, Philip Hewitt, Michael J. Parnham, Katherina Sewald, Susanne Schiffmann

引用次数: 0

摘要

药物引起的肝毒性是药品未获批准和上市后撤消的一个主要原因。在许多情况下，临床前模型缺乏对肝损伤的预测能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IL-2-mediated hepatotoxicity: knowledge gap identification based on the irAOP concept

Drug-induced hepatotoxicity constitutes a major reason for non-approval and post-marketing withdrawal of pharmaceuticals. In many cases, preclinical models lack predictive capacity for hepatic dama...

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来源期刊

Journal of Immunotoxicology 医学-毒理学

CiteScore

6.70

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Immunotoxicology is an open access, peer-reviewed journal that provides a needed singular forum for the international community of immunotoxicologists, immunologists, and toxicologists working in academia, government, consulting, and industry to both publish their original research and be made aware of the research findings of their colleagues in a timely manner. Research from many subdisciplines are presented in the journal, including the areas of molecular, developmental, pulmonary, regulatory, nutritional, mechanistic, wildlife, and environmental immunotoxicology, immunology, and toxicology. Original research articles as well as timely comprehensive reviews are published.